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    Dera Deoxyribose-phosphate aldolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36358, updated on 10-May-2024

    Summary

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    Official Symbol
    Deraprovided by FlyBase
    Official Full Name
    Deoxyribose-phosphate aldolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033735
    Locus tag
    Dmel_CG8525
    See related
    AllianceGenome:FB:FBgn0033735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8525; Dmel\CG8525
    Summary
    Predicted to enable deoxyribose-phosphate aldolase activity. Predicted to be involved in carbohydrate catabolic process and deoxyribonucleotide catabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; spermatozoon; trunk mesoderm; and wing disc. Orthologous to human DERA (deoxyribose-phosphate aldolase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Dera in Genome Data Viewer
    Location:
    49A4-49A4; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12425483..12426975)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8312988..8314480)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 54kD Neighboring gene uncharacterized protein Neighboring gene Deubiquitinating apoptotic inhibitor Neighboring gene Transmembrane protein 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. Nallasivan MP, et al. BMC Biol, 2021 Oct 20. PMID 34666772, Free PMC Article
    2. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article
    3. Intestinal response to dietary manganese depletion in Drosophila. Vásquez-Procopio J, et al. Metallomics, 2020 Feb 1. PMID 31799578
    4. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article
    5. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deoxyribose-phosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribose-phosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deoxyribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deoxyribonucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Deoxyribose-phosphate aldolase
    Names
    CG8525-PA
    CG8525-PD
    Dera-PA
    Dera-PD
    NP_001286348.1
    NP_610781.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12425483..12426975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136937.3 → NP_610781.1  Deoxyribose-phosphate aldolase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NPB3, Q7K209
      Related
      FBpp0087038
      Conserved Domains (1) summary
      cd00959
      Location:56 → 302
      DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family

    2. NM_001299419.1 → NP_001286348.1  Deoxyribose-phosphate aldolase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NPB3, Q7K209
      Conserved Domains (1) summary
      cd00959
      Location:56 → 302
      DeoC; 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K209 Q7K209

    Gene LinkOut

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