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    CG42594 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674091, updated on 10-May-2024

    Summary

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    Official Symbol
    CG42594provided by FlyBase
    Primary source
    FLYBASE:FBgn0260971
    Locus tag
    Dmel_CG42594
    See related
    AllianceGenome:FB:FBgn0260971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15470; CG32770; CG32771; CG6952; Dmel\CG42594
    Old locus tag
    Dmel_CG15470; Dmel_CG32770; Dmel_CG32771
    Summary
    Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG42594 in Genome Data Viewer
    Location:
    4D2-4D5; 1-9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4840833..4906575)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4734866..4800608)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45516 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43495 Neighboring gene boilerman Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonsense-mediated decay enables intron gain in Drosophila. Farlow A, et al. PLoS Genet, 2010 Jan 22. PMID 20107520, Free PMC Article
    2. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
    3. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
    4. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
    5. Operation of a homeostatic sleep switch. Pimentel D, et al. Nature, 2016 Aug 18. PMID 27487216, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42594-PA
    CG42594-PC
    CG42594-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4840833..4906575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297940.1 → NP_001284869.1  uncharacterized protein Dmel_CG42594, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJG8
      Conserved Domains (2) summary
      pfam00520
      Location:601 → 640
      Ion_trans; Ion transport protein
      pfam07885
      Location:599 → 656
      Ion_trans_2; Ion channel

    2. NM_001169196.3 → NP_001162667.1  uncharacterized protein Dmel_CG42594, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJG8
      Conserved Domains (2) summary
      pfam00520
      Location:601 → 640
      Ion_trans; Ion transport protein
      pfam07885
      Location:599 → 656
      Ion_trans_2; Ion channel

    3. NM_001169197.3 → NP_001162668.2  uncharacterized protein Dmel_CG42594, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162668.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJG7
      Conserved Domains (2) summary
      pfam00520
      Location:601 → 640
      Ion_trans; Ion transport protein
      pfam07885
      Location:599 → 656
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJG7 E1JJG7
    E1JJG8 E1JJG8

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