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    Git2 GIT ArfGAP 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304546, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Git2provided by RGD
    Official Full Name
    GIT ArfGAP 2provided by RGD
    Primary source
    RGD:1359708
    See related
    Ensembl:ENSRNOG00000001190 AllianceGenome:RGD:1359708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAT2; CAT-2
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within behavioral response to pain. Predicted to be located in nucleoplasm. Predicted to be active in calyx of Held. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 360.4), Lung (RPKM 268.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Git2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47490350..47531232)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41829717..41872621)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47590110..47630991)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 12 open reading frame 76 Neighboring gene ankyrin repeat domain 13a Neighboring gene uncharacterized LOC102547088 Neighboring gene trichoplein, keratin filament binding Neighboring gene glycolipid transfer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats. Chadwick W, et al. PLoS One, 2012. PMID 22606319, Free PMC Article
    2. The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells. Gavina M, et al. Biol Cell, 2010 Jan 14. PMID 19912111, Free PMC Article
    3. Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Montesinos MS, et al. Neuron, 2015 Dec 2. PMID 26637799, Free PMC Article
    4. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. Bagrodia S, et al. J Biol Chem, 1999 Aug 6. PMID 10428811
    5. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, et al. Nat Neurosci, 2007 Mar. PMID 17310244

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. potentially identified the G protein-coupled receptor/cytoskeletal-associated protein GIT2 as a vital integrator and modulator of the normal aging process
      Title: GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats.
    2. Rat basophilic leukaemia RBL-2H3 cells stably transfected with the chemoattractant receptor expressed both GIT1-p21-activated kinase and GIT2-p21-activated kinase endogenous complexes.
      Title: The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94099

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ARF GTPase-activating protein GIT2
    Names
    ARF GAP GIT2
    G protein-coupled receptor kinase interacting ArfGAP 2
    G protein-coupled receptor kinase-interactor 2
    GRK-interacting protein 2
    cool-interacting tyrosine-phosphorylated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005553.1 → NP_001005553.1  ARF GTPase-activating protein GIT2

      See identical proteins and their annotated locations for NP_001005553.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081967
      UniProtKB/Swiss-Prot
      Q66H91
      UniProtKB/TrEMBL
      A0A8L2UM41
      Related
      ENSRNOP00000048331.3, ENSRNOT00000045946.4
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:637 → 752
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47490350..47531232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249447.5 → XP_006249509.1  ARF GTPase-activating protein GIT2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6G6J8
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:587 → 701
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    2. XM_063271361.1 → XP_063127431.1  ARF GTPase-activating protein GIT2 isoform X12

    3. XM_063271359.1 → XP_063127429.1  ARF GTPase-activating protein GIT2 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZRU3

    4. XM_063271354.1 → XP_063127424.1  ARF GTPase-activating protein GIT2 isoform X2

    5. XM_063271355.1 → XP_063127425.1  ARF GTPase-activating protein GIT2 isoform X3

    6. XM_006249445.5 → XP_006249507.1  ARF GTPase-activating protein GIT2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A5F6, A0A8L2UM41
      Related
      ENSRNOP00000086491.1
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:608 → 722
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    7. XM_063271357.1 → XP_063127427.1  ARF GTPase-activating protein GIT2 isoform X6

    8. XM_006249450.5 → XP_006249512.1  ARF GTPase-activating protein GIT2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6G6J8
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:558 → 672
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    9. XM_006249442.5 → XP_006249504.1  ARF GTPase-activating protein GIT2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UM41
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:637 → 751
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:413 → 477
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    10. XM_063271356.1 → XP_063127426.1  ARF GTPase-activating protein GIT2 isoform X5

    11. XM_063271358.1 → XP_063127428.1  ARF GTPase-activating protein GIT2 isoform X7

    12. XM_063271360.1 → XP_063127430.1  ARF GTPase-activating protein GIT2 isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H91.1 GenPept UniProtKB/Swiss-Prot:Q66H91

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