Slc2a5 solute carrier family 2 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a5provided by RGD
Official Full Name: solute carrier family 2 member 5provided by RGD
Primary source: RGD:68328
See related: Ensembl:ENSRNOG00000017693 AllianceGenome:RGD:68328
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables fructose binding activity; fructose transmembrane transporter activity; and glucose transmembrane transporter activity. Involved in cellular response to fructose stimulus; fructose import across plasma membrane; and glucose transmembrane transport. Located in sarcolemma. Is integral component of plasma membrane. Orthologous to human SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 132.7), Liver (RPKM 58.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (165857412..165892928)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (160583055..160609994)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (167142182..167174203)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively
Title: Structure and mechanism of the mammalian fructose transporter GLUT5.
Hexose transporter-mediated glucose uptake was greater in duodenum and jejunum compared with ileum.
Title: Coordinated, diurnal hexose transporter expression in rat small bowel: implications for small bowel resection.
Vagal innervation appears to differentially mediate the diurnal changes in hexose transporter mRNA and protein expression in the rat jejunum by posttranscriptional, and/or posttranslational processes.
Title: The diurnal periodicity of hexose transporter mRNA and protein levels in the rat jejunum: role of vagal innervation.
investigation of influence of dietary carbohydrates on expression of Glut5 in small intestine: Glut5 mRNA increased with fructose perfusion and age, a pattern that matched that of Pol II binding and histone H3 acetylation at Glut5 promoter
Title: Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine.
regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
Title: Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.
The expression and metabolism of GLUT5 during the postnatal developmental process are reported.
Title: Developmental reprogramming of rat GLUT5 requires glucocorticoid receptor translocation to the nucleus.
The essential role of chloride and fructose absorbing Slc2a5 is reported.
Title: Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.
Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function.
Title: Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function.
insulin is capable of increasing the abundance and functional activity of GLUT5 in skeletal muscle cells, most likely mediated via activation of the GLUT5 promoter
Title: Insulin regulates the expression of the GLUT5 transporter in L6 skeletal muscle cells.
Short-term fructose feeding increases the expression of glucose transporter 5 in both young and aging adult rats. Increased brain expression of glucose transporter 5 is important in the role of fructose as an alternative energy source.
Title: Expression of fructose sensitive glucose transporter in the brains of fructose-fed rats.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fructose binding	IDA Inferred from Direct Assay more info	PubMed
enables fructose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to fructose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fructose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fructose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in fructose import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in fructose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in fructose transmembrane transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in metanephric proximal tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of systemic arterial blood pressure mediated by a chemical signal	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure mediated by a chemical signal	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to fructose	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 5

Names: GLUT-5; fructose transporter; glucose transporter type 5, small intestine; solute carrier family 2 (facilitated glucose transporter), member 5; solute carrier family 2 (facilitated glucose/fructose transporter), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031741.1 → NP_113929.1 solute carrier family 2, facilitated glucose transporter member 5

See identical proteins and their annotated locations for NP_113929.1

Status: PROVISIONAL

Source sequence(s)

D13871

UniProtKB/TrEMBL

A0A8I5ZM52

Related

ENSRNOP00000024054.5, ENSRNOT00000024054.6

Conserved Domains (2) summary

cd06174
Location:71 → 459

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:19 → 474

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

165857412..165892928

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288368.1 → XP_063144438.1 solute carrier family 2, facilitated glucose transporter member 5 isoform X1

UniProtKB/Swiss-Prot

P43427

UniProtKB/TrEMBL

A0A8I5ZM52, B1WBQ4