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    IPP intracisternal A particle-promoted polypeptide [ Homo sapiens (human) ]

    Gene ID: 3652, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IPPprovided by HGNC
    Official Full Name
    intracisternal A particle-promoted polypeptideprovided by HGNC
    Primary source
    HGNC:HGNC:6108
    See related
    Ensembl:ENSG00000197429 MIM:147485; AllianceGenome:HGNC:6108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KLHL27
    Summary
    The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IPP in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45694324..45750653, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45566668..45627842, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46159996..46216325, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1 like 1 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46142481-46142981 Neighboring gene Sharpr-MPRA regulatory region 13545 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46151821-46152419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 987 Neighboring gene transmembrane protein 69 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 834 Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. Kim IF, et al. Gene, 1999 Mar 4. PMID 10072760
    2. The IPP gene is assigned to human chromosome 1p32-1p22. Chang-Yeh A, et al. Genomics, 1993 Jan. PMID 8432546
    3. Identification of a novel murine IAP-promoted placenta-expressed gene. Chang-Yeh A, et al. Nucleic Acids Res, 1991 Jul 11. PMID 1906605, Free PMC Article
    4. Cell lineage-specific expression of the MIPP gene. Mold DE, et al. Biochem Biophys Res Commun, 1991 Jun 28. PMID 1905535
    5. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines. Kim YC, et al. Int J Mol Sci, 2020 Jul 30. PMID 32751711, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
      Title: Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
    2. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
      Title: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding protein IPP
    Names
    kelch-like family member 27
    kelch-like protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145349.2 → NP_001138821.1  actin-binding protein IPP isoform 2

      See identical proteins and their annotated locations for NP_001138821.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK023880, BC032544, DA905423
      Consensus CDS
      CCDS44132.1
      UniProtKB/Swiss-Prot
      Q9Y573
      Related
      ENSP00000353024.4, ENST00000359942.8
      Conserved Domains (2) summary
      PHA03098
      Location:30 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]

    2. NM_005897.3 → NP_005888.1  actin-binding protein IPP isoform 1

      See identical proteins and their annotated locations for NP_005888.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK023880, AL604028, DA905423
      Consensus CDS
      CCDS30702.1
      UniProtKB/Swiss-Prot
      A2A6V4, D3DQ11, Q8N5C3, Q9Y573
      Related
      ENSP00000379739.3, ENST00000396478.4
      Conserved Domains (2) summary
      PHA03098
      Location:30 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45694324..45750653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419673.1 → XP_047275629.1  actin-binding protein IPP isoform X2

    2. XM_006710623.5 → XP_006710686.1  actin-binding protein IPP isoform X3

      Conserved Domains (5) summary
      smart00612
      Location:392 → 437
      Kelch; Kelch domain
      smart00225
      Location:38 → 134
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:333 → 377
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:28 → 131
      BTB; BTB/POZ domain
      pfam07707
      Location:139 → 241
      BACK; BTB And C-terminal Kelch

    3. XM_024446763.2 → XP_024302531.1  actin-binding protein IPP isoform X1

      UniProtKB/Swiss-Prot
      A2A6V4, D3DQ11, Q8N5C3, Q9Y573
      Conserved Domains (2) summary
      PHA03098
      Location:30 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45566668..45627842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336421.1 → XP_054192396.1  actin-binding protein IPP isoform X2

    2. XM_054336424.1 → XP_054192399.1  actin-binding protein IPP isoform X3

    3. XM_054336420.1 → XP_054192395.1  actin-binding protein IPP isoform X1

      UniProtKB/Swiss-Prot
      A2A6V4, D3DQ11, Q8N5C3, Q9Y573

    4. XM_054336422.1 → XP_054192397.1  actin-binding protein IPP isoform X4

    5. XM_054336423.1 → XP_054192398.1  actin-binding protein IPP isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y573.1 GenPept UniProtKB/Swiss-Prot:Q9Y573

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