Lsr lipolysis stimulated lipoprotein receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lsrprovided by RGD
Official Full Name: lipolysis stimulated lipoprotein receptorprovided by RGD
Primary source: RGD:69236
See related: Ensembl:ENSRNOG00000021053 AllianceGenome:RGD:69236
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lisch7
Summary: Predicted to enable fatty acid binding activity and triglyceride binding activity. Involved in regulation of lipid metabolic process. Predicted to be integral component of membrane. Predicted to be part of chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in plasma membrane and tricellular tight junction. Orthologous to human LSR (lipolysis stimulated lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 220.7), Kidney (RPKM 131.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95313830..95329471, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86185769..86201952, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89383515..89399041, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight Junctions of Pancreatic Ductal Epithelial Cells in Hypertriglyceridemic Acute Pancreatitis.
Title: Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight Junctions of Pancreatic Ductal Epithelial Cells in Hypertriglyceridemic Acute Pancreatitis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144092 (e-PCR)
- UniSTS:233338

UniSTS:498304 (e-PCR)
- UniSTS:498304

Lsr (e-PCR), detects polymorphism
- UniSTS:498304

BQ210915 (e-PCR)
- UniSTS:261033

Lsr (e-PCR), detects polymorphism
- UniSTS:498390

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	TAS Traceable Author Statement more info	PubMed
enables triglyceride binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of blood-brain barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in liver development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to tricellular tight junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricellular tight junction assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in tight junction	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in tricellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in tricellular tight junction	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipolysis-stimulated lipoprotein receptor

Names: lipolysis-stimulated receptor; lipolysis-stimulated remnant receptor; liver-specific bHLH-Zip transcription factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032616.2 → NP_116005.1 lipolysis-stimulated lipoprotein receptor precursor

See identical proteins and their annotated locations for NP_116005.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q497B9, Q9WU74, Q9WU75, Q9WU76

UniProtKB/TrEMBL

A0A8I6GKQ0, A6JA42

Related

ENSRNOP00000041379.2, ENSRNOT00000044678.6

Conserved Domains (1) summary

pfam12871
Location:470 → 531

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95313830..95329471 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228845.5 → XP_006228907.1 lipolysis-stimulated lipoprotein receptor isoform X2

See identical proteins and their annotated locations for XP_006228907.1

UniProtKB/TrEMBL

A0A8I6GKQ0, A6JA40

Related

ENSRNOP00000097477.1

Conserved Domains (1) summary

pfam12871
Location:402 → 463

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
XM_006228844.5 → XP_006228906.1 lipolysis-stimulated lipoprotein receptor isoform X1

See identical proteins and their annotated locations for XP_006228906.1

UniProtKB/TrEMBL

A0A8I6GKQ0, A6JA41

Related

ENSRNOP00000028585.3

Conserved Domains (2) summary

pfam08648
Location:451 → 512

DUF1777; Protein of unknown function (DUF1777)

pfam12871
Location:451 → 512

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term