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    Amotl1 angiomotin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315430, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Amotl1provided by RGD
    Official Full Name
    angiomotin-like 1provided by RGD
    Primary source
    RGD:1305268
    See related
    Ensembl:ENSRNOG00000008990 AllianceGenome:RGD:1305268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Predicted to be part of COP9 signalosome. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 685.2), Lung (RPKM 153.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amotl1 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (19630139..19749027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (11348651..11467564, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (13037265..13157701, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4D Neighboring gene CWC15 spliceosome-associated protein Neighboring gene uncharacterized LOC134479993 Neighboring gene piwi-like RNA-mediated gene silencing 4 Neighboring gene sodium channel modifier 1, pseudogene 1 Neighboring gene fucosyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JEAP, a novel component of tight junctions in exocrine cells. Nishimura M, et al. J Biol Chem, 2002 Feb 15. PMID 11733531
    2. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Patrie KM. Biochim Biophys Acta, 2005 Aug 15. PMID 16019084
    3. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Sugihara-Mizuno Y, et al. Genes Cells, 2007 Apr. PMID 17397395
    4. Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Zheng Y, et al. Circ Res, 2009 Jul 31. PMID 19590046
    5. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of epithelial cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angiomotin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429440.1 → NP_001416369.1  angiomotin-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5Y7F3, F1LZQ6

    2. NM_001429441.1 → NP_001416370.1  angiomotin-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A227, F1LZQ6

    3. NM_001429442.1 → NP_001416371.1  angiomotin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1LZQ6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      19630139..19749027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082231.2 → XP_038938159.1  angiomotin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      F1LZQ6
      Conserved Domains (2) summary
      COG1196
      Location:520 → 743
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:657 → 863
      Angiomotin_C; Angiomotin C terminal

    2. XM_039082232.2 → XP_038938160.1  angiomotin-like protein 1 isoform X3

      Related
      ENSRNOP00000077333.1
      Conserved Domains (2) summary
      COG1196
      Location:513 → 736
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:650 → 856
      Angiomotin_C; Angiomotin C terminal

    3. XM_039082230.2 → XP_038938158.1  angiomotin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LZQ6
      Conserved Domains (2) summary
      COG1196
      Location:521 → 744
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:658 → 864
      Angiomotin_C; Angiomotin C terminal

    4. XM_039082234.2 → XP_038938162.1  angiomotin-like protein 1 isoform X6

      UniProtKB/TrEMBL
      F1LZQ6
      Conserved Domains (2) summary
      COG1196
      Location:390 → 613
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:527 → 733
      Angiomotin_C; Angiomotin C terminal

    5. XM_039082233.2 → XP_038938161.1  angiomotin-like protein 1 isoform X4

      Related
      ENSRNOP00000084828.1
      Conserved Domains (2) summary
      COG1196
      Location:476 → 699
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:613 → 819
      Angiomotin_C; Angiomotin C terminal

    6. XM_063266287.1 → XP_063122357.1  angiomotin-like protein 1 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108126.1: Suppressed sequence

      Description
      NM_001108126.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: Amotl1 (GeneID:75723).
    Nucleotide Protein Strain
    Heading Accession and Version

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