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    Pnck pregnancy up-regulated nonubiquitous CaM kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29660, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pnckprovided by RGD
    Official Full Name
    pregnancy up-regulated nonubiquitous CaM kinaseprovided by RGD
    Primary source
    RGD:69249
    See related
    Ensembl:ENSRNOG00000058317 AllianceGenome:RGD:69249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Camk1b
    Summary
    Enables calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human PNCK (pregnancy up-regulated nonubiquitous CaM kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 79.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pnck in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156520751..156524828, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151369406..151373508, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157150071..157154558)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28 like 2 Neighboring gene dual specificity phosphatase 9 Neighboring gene solute carrier family 6 member 8 Neighboring gene B-cell receptor-associated protein 31 Neighboring gene ATP binding cassette subfamily D member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isoform-specific activation and structural diversity of calmodulin kinase I. Naito Y, et al. J Biol Chem, 1997 Dec 19. PMID 9405489
    2. Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms. Tokumitsu H, et al. Biochemistry, 2001 Nov 20. PMID 11705382
    3. Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms. Yokokura H, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074610
    4. Ca(2+)/CaM-dependent kinases: from activation to function. Hook SS, et al. Annu Rev Pharmacol Toxicol, 2001. PMID 11264466
    5. Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Yurimoto S, et al. Biochemistry, 2009 May 12. PMID 19292454

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1B
    Names
    Protein Kinase-like
    caM kinase I beta
    caM kinase IB
    caM-KI beta
    caMKI-beta
    calcium/calmodulin-dependent protein kinase 1, beta
    pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog
    pregnancy upregulated non-ubiquitously expressed CaM kinase
    NP_058971.1
    XP_006229634.1
    XP_006229635.1
    XP_006229637.1
    XP_008771850.1
    XP_063135942.1
    XP_063135943.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017275.2 → NP_058971.1  calcium/calmodulin-dependent protein kinase type 1B

      See identical proteins and their annotated locations for NP_058971.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      O08767, O70150
      UniProtKB/TrEMBL
      A6KRX2, A6KRX3
      Related
      ENSRNOP00000074179.1, ENSRNOT00000090795.2
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156520751..156524828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229573.5 → XP_006229635.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      See identical proteins and their annotated locations for XP_006229635.1

      UniProtKB/Swiss-Prot
      O08767, O70150
      UniProtKB/TrEMBL
      A6KRX2, A6KRX3
      Related
      ENSRNOP00000094811.1
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    2. XM_063279872.1 → XP_063135942.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      UniProtKB/Swiss-Prot
      O08767, O70150
      UniProtKB/TrEMBL
      A6KRX3

    3. XM_006229572.5 → XP_006229634.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

      See identical proteins and their annotated locations for XP_006229634.1

      UniProtKB/TrEMBL
      A6KRX1, A6KRX2
      Conserved Domains (2) summary
      smart00220
      Location:18 → 273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14169
      Location:14 → 290
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    4. XM_063279873.1 → XP_063135943.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

    5. XM_006229575.5 → XP_006229637.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      See identical proteins and their annotated locations for XP_006229637.1

      UniProtKB/Swiss-Prot
      O08767, O70150
      UniProtKB/TrEMBL
      A6KRX2, A6KRX3
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

    6. XM_008773628.4 → XP_008771850.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

      See identical proteins and their annotated locations for XP_008771850.1

      UniProtKB/Swiss-Prot
      O08767, O70150
      UniProtKB/TrEMBL
      A6KRX2, A6KRX3
      Conserved Domains (1) summary
      cd14169
      Location:11 → 287
      STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70150.1 GenPept UniProtKB/Swiss-Prot:O70150

    Gene LinkOut

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