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    Nudt12 nudix hydrolase 12 [ Mus musculus (house mouse) ]

    Gene ID: 67993, updated on 9-May-2024

    Summary

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    Official Symbol
    Nudt12provided by MGI
    Official Full Name
    nudix hydrolase 12provided by MGI
    Primary source
    MGI:MGI:1915243
    See related
    Ensembl:ENSMUSG00000024228 AllianceGenome:MGI:1915243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610016O18Rik
    Summary
    Enables RNA NAD-cap (NMN-forming) hydrolase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in NAD-cap decapping; circadian regulation of gene expression; and mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Is expressed in eye. Orthologous to human NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 3.4), kidney adult (RPKM 2.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt12 in Genome Data Viewer
    Location:
    17 D; 17 30.64 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (59307104..59320317, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (59000107..59013367, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene general transcription factor III A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42933 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene predicted gene, 33751 Neighboring gene STARR-seq mESC enhancer starr_42935 Neighboring gene nudix hydrolase 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42936 Neighboring gene STARR-seq mESC enhancer starr_42937 Neighboring gene nuclear encoded tRNA valine 3 (anticodon CAC) Neighboring gene predicted gene, 23769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. Sharma S, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32432673, Free PMC Article
    2. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim SR, et al. Biochem J, 2003 Sep 1. PMID 12790796, Free PMC Article
    3. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Grudzien-Nogalska E, et al. Nat Chem Biol, 2019 Jun. PMID 31101919, Free PMC Article
    4. Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs. Wu H, et al. Cell Rep, 2019 Dec 24. PMID 31875550
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
      Title: Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables RNA NAD-cap (NMN-forming) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphodiesterase decapping endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NAD catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in NAD catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD-cap decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD-cap decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in NADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA methylguanosine-cap decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD-capped RNA hydrolase NUDT12
    Names
    NADH pyrophosphatase NUDT12
    deNADding enzyme NUDT12
    nucleoside diphosphate-linked moiety X motif 12
    nudix (nucleoside diphosphate linked moiety X)-type motif 12
    nudix (nucleoside diphosphnudix (nucleoside diphosphate linked moiety X)-type motif 12ate linked moiety X)-type motif 12
    nudix motif 12
    peroxisomal NADH pyrophosphatase NUDT12
    NP_001355322.1
    NP_080773.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368393.1 → NP_001355322.1  NAD-capped RNA hydrolase NUDT12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009564

    2. NM_026497.3 → NP_080773.1  NAD-capped RNA hydrolase NUDT12 isoform 1

      See identical proteins and their annotated locations for NP_080773.1

      Status: VALIDATED

      Source sequence(s)
      AK002641, CT009564
      Consensus CDS
      CCDS28933.1
      UniProtKB/Swiss-Prot
      Q6PFA5, Q9DCN1
      UniProtKB/TrEMBL
      Q3UGL8
      Related
      ENSMUSP00000025065.6, ENSMUST00000025065.12
      Conserved Domains (7) summary
      COG2816
      Location:126 → 457
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd00204
      Location:16 → 98
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03429
      Location:323 → 457
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:147 → 277
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:279 → 302
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
      pfam13857
      Location:31 → 86
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:14 → 43
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      59307104..59320317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCN1.1 GenPept UniProtKB/Swiss-Prot:Q9DCN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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