SLC47A2 solute carrier family 47 member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC47A2provided by HGNC
Official Full Name: solute carrier family 47 member 2provided by HGNC
Primary source: HGNC:HGNC:26439
See related: Ensembl:ENSG00000180638 MIM:609833; AllianceGenome:HGNC:26439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MATE2; MATE2K; MATE2-B; MATE2-K
Summary: This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward kidney (RPKM 17.1) See more
Orthologs: all
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Genomic context

Location:: 17p11.2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (19678317..19718979, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (19626936..19667598, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (19581630..19622292, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans.
Title: Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans.
Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
Title: Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
the SLC47A2 locus highly expresses SANT1, which can remove the regulatory SFPQ/E2F1/HDAC1 suppressor complex from the promoter region.
Title: A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma.
The studied SLC47A1 and SLC47A2 SNPs had no influence on the dose requirement or adverse effects of metformin.
Title: Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the glycemic response to metformin in type 2 diabetes mellitus patients.
SLC47A2 transcriptional repression in Renal Cell Carcinoma tissues.
Title: Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma.
The impact of assay conditions on IC50 determination is negligible, kinetic characteristics differ among used test substrates, and substrate-dependent inhibition exists for MATE1 and MATE2-K, giving valuable insight into the assessment of clinically relevant MATE-mediated drug interactions in vitro.
Title: Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.
Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
Title: Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin.
Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 signaling
Title: Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation.
There were statistically significant association between resistance to metformin and MATE2 expression in cancer cells.
Title: MATE2 Expression Is Associated with Cancer Cell Response to Metformin.
These were associated with markedly reduced or increased MATE2-K function.
Title: Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables polyspecific organic cation:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	TAS Traceable Author Statement more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	TAS Traceable Author Statement more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: multidrug and toxin extrusion protein 2

Names: kidney-specific H(+)/organic cation antiporter; solute carrier family 47 (multidrug and toxin extrusion), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052805.1 RefSeqGene

Range

7396..45663

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001099646.3 → NP_001093116.1 multidrug and toxin extrusion protein 2 isoform 2

See identical proteins and their annotated locations for NP_001093116.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as MATE2-K), compared to isoform 1.

Source sequence(s)

AB250364, AC005722

Consensus CDS

CCDS92273.1

UniProtKB/Swiss-Prot

Q86VL8

Related

ENSP00000391848.3, ENST00000433844.4

Conserved Domains (2) summary

COG0534
Location:33 → 467

NorM; Na+-driven multidrug efflux pump [Defense mechanisms]

cd13132
Location:30 → 464

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
NM_001256663.3 → NP_001243592.1 multidrug and toxin extrusion protein 2 isoform 3

See identical proteins and their annotated locations for NP_001243592.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and contains an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AB250364, BC035288, DA312379

Consensus CDS

CCDS58530.1

UniProtKB/Swiss-Prot

Q86VL8

Related

ENSP00000338084.6, ENST00000350657.9

Conserved Domains (2) summary

COG0534
Location:33 → 481

NorM; Na+-driven multidrug efflux pump [Defense mechanisms]

cd13132
Location:30 → 478

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
NM_152908.5 → NP_690872.2 multidrug and toxin extrusion protein 2 isoform 1

See identical proteins and their annotated locations for NP_690872.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1), also known as MATE2.

Source sequence(s)

AC005722, BC050578

Consensus CDS

CCDS11211.1

UniProtKB/Swiss-Prot

A0JBX9, A0P8Z7, Q63HJ9, Q86VL8, Q8IV44, Q96NA1

Related

ENSP00000326671.5, ENST00000325411.9

Conserved Domains (2) summary

COG0534
Location:33 → 503

NorM; Na+-driven multidrug efflux pump [Defense mechanisms]

cd13132
Location:30 → 500

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RNA

NR_135624.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AB250364, BC035288, BX648861

Related

ENST00000463318.5
NR_135625.3 RNA Sequence

Status: REVIEWED

Source sequence(s)

AB250701, AK307647, BC035288

Related

ENST00000574239.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

19678317..19718979 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024222.3 → XP_016879711.1 multidrug and toxin extrusion protein 2 isoform X2
XM_017024221.2 → XP_016879710.1 multidrug and toxin extrusion protein 2 isoform X1
XM_047435435.1 → XP_047291391.1 multidrug and toxin extrusion protein 2 isoform X6
XM_047435434.1 → XP_047291390.1 multidrug and toxin extrusion protein 2 isoform X4
XM_017024223.2 → XP_016879712.1 multidrug and toxin extrusion protein 2 isoform X3

UniProtKB/TrEMBL

C9JAE6
XM_017024224.2 → XP_016879713.1 multidrug and toxin extrusion protein 2 isoform X5

UniProtKB/TrEMBL

C9JAE6
XM_017024226.2 → XP_016879715.1 multidrug and toxin extrusion protein 2 isoform X8

UniProtKB/TrEMBL

C9JAE6
XM_017024225.2 → XP_016879714.1 multidrug and toxin extrusion protein 2 isoform X7

RNA

XR_001752432.2 RNA Sequence
XR_001752433.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

19626936..19667598 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315164.1 → XP_054171139.1 multidrug and toxin extrusion protein 2 isoform X2
XM_054315163.1 → XP_054171138.1 multidrug and toxin extrusion protein 2 isoform X1
XM_054315168.1 → XP_054171143.1 multidrug and toxin extrusion protein 2 isoform X6
XM_054315166.1 → XP_054171141.1 multidrug and toxin extrusion protein 2 isoform X4
XM_054315165.1 → XP_054171140.1 multidrug and toxin extrusion protein 2 isoform X3
XM_054315167.1 → XP_054171142.1 multidrug and toxin extrusion protein 2 isoform X5
XM_054315170.1 → XP_054171145.1 multidrug and toxin extrusion protein 2 isoform X8
XM_054315169.1 → XP_054171144.1 multidrug and toxin extrusion protein 2 isoform X7