tfap2b transcription factor AP-2 beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfap2bprovided by ZNC
Official Full Name: transcription factor AP-2 betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-394
See related: Ensembl:ENSDARG00000012667 AllianceGenome:ZFIN:ZDB-GENE-050417-394
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110163; si:dkey-5e16.1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cartilage development. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; nervous system; pharyngeal arch; pronephros; and ventral mesoderm. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (47688719..47706993, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (48211718..48229966, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Title: TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential.
Title: Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential.
tfap2b and its close relative, tfap2a, play redundant roles in the ectoderm to control skeletogenesis of neural crest cells
Title: AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor AP-2-beta

Names: ap2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017847.1 → NP_001017847.1 transcription factor AP-2-beta isoform 1

See identical proteins and their annotated locations for NP_001017847.1

Status: PROVISIONAL

Source sequence(s)

BC092766

UniProtKB/TrEMBL

Q561Y4

Conserved Domains (1) summary

pfam03299
Location:178 → 234

TF_AP-2; Transcription factor AP-2
NM_001024665.1 → NP_001019836.1 transcription factor AP-2-beta isoform 2

See identical proteins and their annotated locations for NP_001019836.1

Status: PROVISIONAL

Source sequence(s)

DQ060246

UniProtKB/TrEMBL

Q4TTV4

Related

ENSDARP00000143375.2, ENSDART00000174808.2

Conserved Domains (1) summary

pfam03299
Location:209 → 407

TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

47688719..47706993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160883.4 → XP_005160940.1 transcription factor AP-2-beta isoform X1

UniProtKB/TrEMBL

A0A8M2B7U7

Conserved Domains (1) summary

pfam03299
Location:227 → 425

TF_AP-2; Transcription factor AP-2