slc25a39 solute carrier family 25 member 39 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc25a39provided by ZNC
Official Full Name: solute carrier family 25 member 39provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1250
See related: Ensembl:ENSDARG00000007449 AllianceGenome:ZFIN:ZDB-GENE-040426-1250
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63736
Summary: Predicted to enable metallochaperone activity. Acts upstream of or within heme biosynthetic process. Predicted to be located in mitochondrion. Is expressed in intermediate cell mass of mesoderm. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (29872818..29891495, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (29741976..29760653, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis.
Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metallochaperone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione import into mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within manganese ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within mitochondrial transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: mitochondrial glutathione transporter SLC25A39; solute carrier family 25 member 39

Names: probable mitochondrial glutathione transporter SLC25A39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200486.1 → NP_956780.1 mitochondrial glutathione transporter SLC25A39

See identical proteins and their annotated locations for NP_956780.1

Status: PROVISIONAL

Source sequence(s)

BC055226

UniProtKB/Swiss-Prot

Q7SXW0

Related

ENSDARP00000005911.6, ENSDART00000014021.8

Conserved Domains (1) summary

pfam00153
Location:250 → 351

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

29872818..29891495 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163929.4 → XP_005163986.1 solute carrier family 25 member 39 isoform X2

UniProtKB/TrEMBL

A0A8M2BBF8

Conserved Domains (1) summary

pfam00153
Location:163 → 246

Mito_carr; Mitochondrial carrier protein
XM_005163931.4 → XP_005163988.1 solute carrier family 25 member 39 isoform X4

UniProtKB/TrEMBL

A0A8M2BB72

Conserved Domains (2) summary

PTZ00169
Location:20 → 319

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:13 → 133

Mito_carr; Mitochondrial carrier protein
XM_005163930.4 → XP_005163987.1 solute carrier family 25 member 39 isoform X3

UniProtKB/TrEMBL

A0A8M2BB41

Conserved Domains (2) summary

PTZ00169
Location:20 → 320

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:13 → 133

Mito_carr; Mitochondrial carrier protein
XM_021469806.1 → XP_021325481.1 solute carrier family 25 member 39 isoform X1

UniProtKB/TrEMBL

A0A8M9PT31, F1QVQ4

Conserved Domains (1) summary

pfam00153
Location:250 → 351

Mito_carr; Mitochondrial carrier protein