tcea2 transcription elongation factor A (SII), 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcea2provided by ZNC
Official Full Name: transcription elongation factor A (SII), 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-985
See related: Ensembl:ENSDARG00000012927 AllianceGenome:ZFIN:ZDB-GENE-040426-985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56325
Summary: Predicted to enable translation elongation factor activity and zinc ion binding activity. Predicted to be involved in transcription, DNA-templated. Predicted to act upstream of or within regulation of transcription, DNA-templated and translational elongation. Predicted to be active in nucleus. Is expressed in lens; olfactory placode; and peripheral olfactory organ. Orthologous to human TCEA2 (transcription elongation factor A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (8718950..8733092, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (8783980..8798122, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription elongation factor A protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200986.2 → NP_957280.2 transcription elongation factor A protein 2

Status: VALIDATED

Source sequence(s)

CR457456, EH452133, EH458327, EH477932

UniProtKB/TrEMBL

A0A8M1PDT9, F1QTS2

Related

ENSDARP00000002994.8, ENSDART00000014222.9

Conserved Domains (4) summary

cd00183
Location:5 → 80

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

cd13749
Location:254 → 300

Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS

TIGR01385
Location:6 → 301

TFSII; transcription elongation factor S-II

pfam07500
Location:138 → 245

TFIIS_M; Transcription factor S-II (TFIIS), central domain