hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hadhbprovided by ZNC
Official Full Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8550
See related: Ensembl:ENSDARG00000102055 AllianceGenome:ZFIN:ZDB-GENE-030131-8550
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb14g10; zgc:56274; wu:fb14g10
Summary: Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in female organism. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (47931983..47952747, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (48463500..48484263, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj79g04.y1 (e-PCR)
- UniSTS:199936

fb14g10.x1 (e-PCR)
- UniSTS:202935

fj93h07.y1 (e-PCR)
- UniSTS:200382

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trifunctional enzyme subunit beta, mitochondrial

Names: dehydrogenase/3-ketoacyl-Coenzyme A thiolase; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

NP_956313.1

EC 2.3.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200019.1 → NP_956313.1 trifunctional enzyme subunit beta, mitochondrial

See identical proteins and their annotated locations for NP_956313.1

Status: PROVISIONAL

Source sequence(s)

BC046041

UniProtKB/TrEMBL

Q7ZTH6

Related

ENSDARP00000151192.1, ENSDART00000167986.3

Conserved Domains (2) summary

cd00751
Location:52 → 468

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

TIGR01930
Location:54 → 467

AcCoA-C-Actrans; acetyl-CoA acetyltransferases