zranb2 zinc finger, RAN-binding domain containing 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zranb2provided by ZNC
Official Full Name: zinc finger, RAN-binding domain containing 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2743
See related: Ensembl:ENSDARG00000044332 AllianceGenome:ZFIN:ZDB-GENE-040426-2743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56597; wu:fa96h03
Summary: Enables lipid antigen binding activity and lipopolysaccharide binding activity. Acts upstream of or within defense response to bacterium. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural tube; blastoderm; blastodisc; integument; and pleuroperitoneal region. Orthologous to human ZRANB2 (zinc finger RANBP2-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (37301341..37307487)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (37323447..37329593)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results indicate that ZRANB2 is a maternal LPS-binding protein that can protect the early embryos of zebrafish against pathogenic attacks, a novel role ever assigned to ZRANB2 proteins.
Title: Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections.

Submit: New GeneRIF Correction

General gene information

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Markers

fi24d02.y1 (e-PCR)
- UniSTS:197083

fa96h03 (e-PCR)
- UniSTS:188912

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables lipid antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger Ran-binding domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328210.1 → NP_001315139.1 zinc finger Ran-binding domain-containing protein 2

Status: VALIDATED

Source sequence(s)

BX324166

UniProtKB/TrEMBL

A0A8M1P4J9, E7F1Q7

Related

ENSDARP00000094955.3, ENSDART00000104180.4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

37301341..37307487

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356460.2 → XP_017211949.1 zinc finger Ran-binding domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M6Z7B1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_213407.1: Suppressed sequence

Description

NM_213407.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.