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    nub1 negative regulator of ubiquitin-like proteins 1 [ Danio rerio (zebrafish) ]

    Gene ID: 557021, updated on 27-Mar-2024

    Summary

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    Official Symbol
    nub1provided by ZNC
    Official Full Name
    negative regulator of ubiquitin-like proteins 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080212-11
    See related
    Ensembl:ENSDARG00000061417 AllianceGenome:ZFIN:ZDB-GENE-080212-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171563
    Summary
    Predicted to be involved in regulation of ubiquitin-dependent protein catabolic process. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nub1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (41272958..41303239)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (41409640..41439804)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene activin A receptor type 2Ba Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene crystallin, gamma N2 Neighboring gene Ras homolog, mTORC1 binding

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish. Lin J, et al. J Cereb Blood Flow Metab, 2021 Jun. PMID 32248732, Free PMC Article
    2. Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Huang V, et al. Sci Rep, 2019 Feb 4. PMID 30718621, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8 ultimate buster 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113580.1 → NP_001107052.1  NEDD8 ultimate buster 1

      See identical proteins and their annotated locations for NP_001107052.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154454
      UniProtKB/TrEMBL
      A8WFT9
      Conserved Domains (4) summary
      cd01769
      Location:108 → 158
      UBL; Ubiquitin-like domain of UBL
      cd14291
      Location:369 → 404
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14292
      Location:427 → 461
      UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:470 → 505
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      41272958..41303239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170646.4 → XP_005170703.1  NEDD8 ultimate buster 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHY2
      Conserved Domains (4) summary
      cd01769
      Location:100 → 157
      UBL; Ubiquitin-like domain of UBL
      cd14291
      Location:369 → 404
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14292
      Location:427 → 461
      UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:474 → 508
      UBA_like_SF; UBA domain-like superfamily

    2. XM_009297673.3 → XP_009295948.1  NEDD8 ultimate buster 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AW93
      Related
      ENSDARP00000128904.1, ENSDART00000155151.2
      Conserved Domains (4) summary
      cd01769
      Location:100 → 157
      UBL; Ubiquitin-like domain of UBL
      cd14291
      Location:369 → 404
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cd14292
      Location:427 → 461
      UBA2_NUB1; UBA2 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:474 → 508
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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