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    ssr1 signal sequence receptor, alpha [ Danio rerio (zebrafish) ]

    Gene ID: 373100, updated on 27-Mar-2024

    Summary

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    Official Symbol
    ssr1provided by ZNC
    Official Full Name
    signal sequence receptor, alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-28
    See related
    Ensembl:ENSDARG00000101627 AllianceGenome:ZFIN:ZDB-GENE-030826-28
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb758
    Summary
    Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axis; fin; hatching gland; periderm; and polster. Orthologous to human SSR1 (signal sequence receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ssr1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (42080255..42090640, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (42110455..42120840, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene VAMP (vesicle-associated membrane protein)-associated protein A Neighboring gene serine-aspartate repeat-containing protein F-like Neighboring gene aryl-hydrocarbon receptor repressor a Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Ayobahan SU, et al. Chemosphere, 2020 Feb. PMID 31726584
    2. Investigation of the effects of estrogen on skeletal gene expression during zebrafish larval head development. Pashay Ahi E, et al. PeerJ, 2016. PMID 27069811, Free PMC Article
    3. Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Liu Y, et al. Front Genet, 2020. PMID 32849832, Free PMC Article
    4. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article
    5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201327.1 → NP_958484.1  translocon-associated protein subunit alpha precursor

      See identical proteins and their annotated locations for NP_958484.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056339
      UniProtKB/TrEMBL
      Q8AWW3
      Related
      ENSDARP00000138716.1, ENSDART00000166413.2
      Conserved Domains (1) summary
      pfam03896
      Location:79 → 284
      TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      42080255..42090640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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