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    acvr2ba activin A receptor type 2Ba [ Danio rerio (zebrafish) ]

    Gene ID: 30457, updated on 11-Apr-2024

    Summary

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    Official Symbol
    acvr2baprovided by ZNC
    Official Full Name
    activin A receptor type 2Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-549
    See related
    Ensembl:ENSDARG00000044422 AllianceGenome:ZFIN:ZDB-GENE-980526-549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    actr2b; acvr2b; actrIIb; wu:fj97d11
    Summary
    Predicted to enable activin binding activity and activin-activated receptor activity. Acts upstream of or within cartilage development; hindbrain development; and neural crest cell migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blastomere; central nervous system; digestive system; gonad; and oral epithelium. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See acvr2ba in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (41164800..41220538, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (41301445..41357193, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 48a Neighboring gene sodium channel, voltage gated, type V-like, alpha b Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene negative regulator of ubiquitin-like proteins 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterizations of an Activin type II receptor orthologue from the pacific oyster Crassostrea gigas. Le Quéré H, et al. Gene, 2009 May 1. PMID 19393178
    2. An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Barone V, et al. Dev Cell, 2017 Oct 23. PMID 29033362
    3. Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Song C, et al. Gen Comp Endocrinol, 2010 Mar 1. PMID 19699739
    4. Cloning of a second form of activin-betaA cDNA and regulation of activin-betaA subunits and activin type II receptor mRNA expression by gonadotropin in the zebrafish ovary. DiMuccio T, et al. Gen Comp Endocrinol, 2005 Sep 15. PMID 15925369
    5. Extracellular interactions and ligand degradation shape the nodal morphogen gradient. Wang Y, et al. Elife, 2016 Apr 21. PMID 27101364, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhbaa signaled through Acvr2a over Acvr2b during zebrafish cardiac regeneration.
      Title: Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair.
    2. Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
      Title: Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables activin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activin receptor type-2B
    Names
    activin A receptor, type IIB
    activin A receptor, type IIBa
    activin receptor IIb
    NP_571285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131210.3 → NP_571285.1  activin receptor type-2B precursor

      See identical proteins and their annotated locations for NP_571285.1

      Status: VALIDATED

      Source sequence(s)
      BC044131, CABZ01072517, CABZ01072518, CU467626
      UniProtKB/TrEMBL
      Q9YGU4
      Related
      ENSDARP00000106562.3, ENSDART00000121592.3
      Conserved Domains (3) summary
      smart00220
      Location:189 → 469
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14140
      Location:192 → 482
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:49 → 117
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      41164800..41220538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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