TAS1R2 taste 1 receptor member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS1R2provided by HGNC
Official Full Name: taste 1 receptor member 2provided by HGNC
Primary source: HGNC:HGNC:14905
See related: Ensembl:ENSG00000179002 MIM:606226; AllianceGenome:HGNC:14905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TR2; T1R2; GPR71
Summary: Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (18839599..18859660, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (18659394..18679451, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (19166093..19186154, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
Title: Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
Title: The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
Title: Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
Title: Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
Title: The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
Title: Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
Title: Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
create several models of the orthosteric binding site of the sweet taste receptor in the hT1R2 VFT domain
Title: Structure-based screening for discovery of sweet compounds.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to sweet taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to sweet taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables taste receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of sweet taste	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sweet taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of sweet taste receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sweet taste receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: taste receptor type 1 member 2

Names: G-protein coupled receptor 71; sweet taste receptor T1R2; taste receptor, type 1, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152232.6 → NP_689418.2 taste receptor type 1 member 2 precursor

See identical proteins and their annotated locations for NP_689418.2

Status: VALIDATED

Source sequence(s)

AL831755, BX537160

Consensus CDS

CCDS187.1

UniProtKB/Swiss-Prot

Q5TZ19, Q8TE23

Related

ENSP00000364520.3, ENST00000375371.4

Conserved Domains (4) summary

cd06363
Location:27 → 484

PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor

pfam00003
Location:577 → 814

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:70 → 454

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:493 → 543

NCD3G; Nine Cysteines Domain of family 3 GPCR