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    Zfp446 zinc finger protein 446 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102552463, updated on 6-Jun-2024

    Summary

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    Symbol
    Zfp446provided by RGD
    Full Name
    zinc finger protein 446provided by RGD
    Primary source
    RGD:7612453
    See related
    Ensembl:ENSRNOG00000060429 AllianceGenome:RGD:7612453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AABR07002065.2
    Summary
    Predicted to enable identical protein binding activity. Orthologous to human ZNF446 (zinc finger protein 446). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 54.0), Kidney (RPKM 35.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp446 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82673920..82680414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73594953..73612685)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65595518..65608757, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482889 Neighboring gene zinc finger protein 324 Neighboring gene solute carrier family 27 member 5 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene uncharacterized LOC108348449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 446

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427845.1 → NP_001414774.1  zinc finger protein 446

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZPP3, A0A8I6ALX6, A6KQM3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      82673920..82680414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589934.3 → XP_017445423.1  zinc finger protein 446 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPP3, A0A8I6ALX6, A6KQM3
      Related
      ENSRNOP00000080472.1
      Conserved Domains (4) summary
      smart00431
      Location:22 → 126
      SCAN; leucine rich region
      sd00017
      Location:323 → 343
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:213 → 239
      KRAB; KRAB box
      pfam02023
      Location:22 → 110
      SCAN; SCAN domain

    2. XM_063286215.1 → XP_063142285.1  zinc finger protein 446 isoform X3

      UniProtKB/TrEMBL
      D4A2E8

    3. XM_017589936.3 → XP_017445425.1  zinc finger protein 446 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPP3, A0A8I6ALX6, A6KQM3
      Conserved Domains (4) summary
      smart00431
      Location:22 → 126
      SCAN; leucine rich region
      sd00017
      Location:323 → 343
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:213 → 239
      KRAB; KRAB box
      pfam02023
      Location:22 → 110
      SCAN; SCAN domain

    4. XM_039100802.2 → XP_038956730.1  zinc finger protein 446 isoform X2

      UniProtKB/TrEMBL
      D4A2E8
      Conserved Domains (2) summary
      cd07765
      Location:213 → 240
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      pfam02023
      Location:22 → 108
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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