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    rpi-1 Protein rpi-1 [ Caenorhabditis elegans ]

    Gene ID: 189281, updated on 12-Jun-2024

    Summary

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    Gene symbol
    rpi-1
    Gene description
    Protein rpi-1
    Locus tag
    CELE_W07G1.5
    See related
    AllianceGenome:WB:WBGene00012332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in intracellular signal transduction. Located in axonemal microtubule; ciliary base; and ciliary transition zone. Is expressed in ciliated neurons. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; dyslexia; nephronophthisis 19; and sclerosing cholangitis. Orthologous to several human genes including DCDC2B (doublecortin domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See rpi-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (13959123..13962419, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene ncRNA Neighboring gene Transcription factor zip-3 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. Jensen VL, et al. PLoS Genet, 2016 Dec. PMID 27930654, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein rpi-1
    NP_001022398.1
    • Confirmed by transcript evidence
    NP_001022399.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13959123..13962419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027228.5 → NP_001022399.1  Protein rpi-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022399.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q69Z08, Q9XUK0
      Conserved Domains (2) summary
      smart00537
      Location:32 → 115
      DCX; Domain in the Doublecortin (DCX) gene product
      cl25751
      Location:123 → 354
      DUF4045; Domain of unknown function (DUF4045)

    2. NM_001027227.4 → NP_001022398.1  Protein rpi-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q69Z08
      Conserved Domains (1) summary
      smart00537
      Location:32 → 115
      DCX; Domain in the Doublecortin (DCX) gene product
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69Z08.1

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