Y48B6A.13 Diphosphomevalonate decarboxylase [Caenorhabditis elegans] - Gene

Summary

Gene symbol: Y48B6A.13
Gene description: Diphosphomevalonate decarboxylase
Primary source: WormBase:WBGene00012984
Locus tag: CELE_Y48B6A.13
See related: AllianceGenome:WB:WBGene00012984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable diphosphomevalonate decarboxylase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables diphosphomevalonate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphomevalonate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

NP_496966.1

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