eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif4ebp1provided by ZNC
Official Full Name: eukaryotic translation initiation factor 4E binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2332
See related: Ensembl:ENSDARG00000043608 AllianceGenome:ZFIN:ZDB-GENE-030131-2332
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc04h09; zgc:64137; wu:fc04h09
Summary: Predicted to enable eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within negative regulation of translation. Predicted to be active in cytoplasm. Is expressed in brain and head. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (21013154..21020608, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (20976518..20983972, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic initiation factor 4E binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199645.1 → NP_955939.1 eukaryotic translation initiation factor 4E-binding protein 1

See identical proteins and their annotated locations for NP_955939.1

Status: PROVISIONAL

Source sequence(s)

BC057433

UniProtKB/TrEMBL

A8KC17, Q6PFS8

Related

ENSDARP00000064031.4, ENSDART00000064032.5

Conserved Domains (1) summary

pfam05456
Location:9 → 120

eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)