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    rfc4 replication factor C (activator 1) 4 [ Danio rerio (zebrafish) ]

    Gene ID: 406435, updated on 25-Apr-2024

    Summary

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    Official Symbol
    rfc4provided by ZNC
    Official Full Name
    replication factor C (activator 1) 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040824-3
    See related
    Ensembl:ENSDARG00000042458 AllianceGenome:ZFIN:ZDB-GENE-040824-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rcf4; zgc:64030
    Summary
    Predicted to enable ATP binding activity and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Acts upstream of or within retina development in camera-type eye. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; immature eye; and nervous system. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See rfc4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (45426607..45435006, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (45049041..45057440, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13C Neighboring gene son of sevenless homolog 1 (Drosophila) Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene gem (nuclear organelle) associated protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells. Kobayashi I, et al. Blood, 2010 Jan 14. PMID 19890097
    2. Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis. Fongang B, et al. PLoS One, 2016. PMID 27192554, Free PMC Article
    3. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
    4. Identification of zebrafish insertional mutants with defects in visual system development and function. Gross JM, et al. Genetics, 2005 May. PMID 15716491, Free PMC Article
    5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 4
    Names
    replication factor C subunit RFC4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214737.2 → NP_999902.2  replication factor C subunit 4

      See identical proteins and their annotated locations for NP_999902.2

      Status: PROVISIONAL

      Source sequence(s)
      AY648805
      UniProtKB/TrEMBL
      Q6DRF4
      Related
      ENSDARP00000130135.1, ENSDART00000163923.2
      Conserved Domains (4) summary
      cd00009
      Location:50 → 196
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK00440
      Location:34 → 346
      rfc; replication factor C small subunit; Reviewed
      pfam08542
      Location:281 → 348
      Rep_fac_C; Replication factor C C-terminal domain
      pfam16193
      Location:212 → 262
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      45426607..45435006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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