mob1a MOB kinase activator 1A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mob1aprovided by ZNC
Official Full Name: MOB kinase activator 1Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6506
See related: Ensembl:ENSDARG00000102320 AllianceGenome:ZFIN:ZDB-GENE-030131-6506
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mobkl1b; zgc:56189; wu:fv69d04
Summary: Predicted to enable protein kinase activator activity. Acts upstream of or within cell population proliferation; central nervous system development; and somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in head. Orthologous to human MOB1A (MOB kinase activator 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (69708528..69716466, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (68935976..68943825, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mats1 plays a critical role in regulating cell proliferation and apoptosis during early development in zebrafish[mats1]
Title: The mob as tumor suppressor (mats1) gene is required for growth control in developing zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MOB kinase activator 1A

Names: MOB1, Mps One Binder kinase activator-like 1B; mats1; mobk1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199914.1 → NP_956208.1 MOB kinase activator 1A

See identical proteins and their annotated locations for NP_956208.1

Status: PROVISIONAL

Source sequence(s)

BC045979

UniProtKB/TrEMBL

Q7ZV70

Related

ENSDARP00000141585.1, ENSDART00000158956.2

Conserved Domains (1) summary

pfam03637
Location:33 → 204

Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

69708528..69716466 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021475960.1 → XP_021331635.1 MOB kinase activator 1A isoform X1

UniProtKB/TrEMBL

A0A8M9QDF4

Related

ENSDART00000159851.2

Conserved Domains (1) summary

pfam03637
Location:33 → 229

Mob1_phocein; Mob1/phocein family