dnd1 DND microRNA-mediated repression inhibitor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnd1provided by ZNC
Official Full Name: DND microRNA-mediated repression inhibitor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030828-4
See related: Ensembl:ENSDARG00000022813 AllianceGenome:ZFIN:ZDB-GENE-030828-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dnd; cb736; wu:fi22d10; zgc:111864
Summary: Enables mRNA 3'-UTR binding activity. Acts upstream of or within several processes, including gamete generation; heart contraction; and mRNA stabilization. Located in P granule and germ cell nucleus. Is expressed in blastodisc; brain; heart; reproductive system; and unfertilized egg. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (7397889..7409019, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (7091480..7102610, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1.
Title: Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1.
The germ cell marker dead end reveals alternatively spliced transcripts with dissimilar expression.
Title: The germ cell marker dead end reveals alternatively spliced transcripts with dissimilar expression.
Homozygous dnd mutants became germ-cell-free males that are able to nurse donor-derived germ cells.
Title: Application of dead end-knockout zebrafish as recipients of germ cell transplantation.
study showed that DND protein functions as a translation repressor of specific mRNAs to control PGC development in zebrafish
Title: DND protein functions as a translation repressor during zebrafish embryogenesis.
Balance between miRNA-430 function and the action of the RNA-binding protein Dead end, effectively transforms immotile primordial germ cells into polarized cells that actively migrate relative to cells in their environment.
Title: Identification and regulation of a molecular module for bleb-based cell motility.
Data show that hub RNA is a target of global miRNA-mediated repression, while the RNA-binding protein Dead end (Dnd) contributes to maintenance of the expression in the primordial germ cells (PGCs).
Title: Regulation of hub mRNA stability and translation by miR430 and the dead end protein promotes preferential expression in zebrafish primordial germ cells.
identification of target mRNA for ZDnd will be helpful to further explore the biological function of Dnd in zebrafish germ-line development as well as in cancer cells
Title: Zebrafish Dnd protein binds to 3'UTR of geminin mRNA and regulates its expression.
Dnd ATPase is involved in protecting primordial germ cell nanos1 and TDRD7 transcripts.
Title: Zebrafish dead end possesses ATPase activity that is required for primordial germ cell development.
Cis-acting elements within dnd mRNA and the RNA recognition motive (RRM) of the protein are essential for targeting protein expression to the germ cells and to the perinuclear granules, respectively.
Title: Control of Dead end localization and activity--implications for the function of the protein in antagonizing miRNA function.
Unravel a novel role of dead end 1 (Dnd1) in protecting certain mRNAs from miRNA-mediated repression.
Title: RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within germ cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of miRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA-mediated gene silencing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell motility	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dead end protein 1

Names: drDnd1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212795.1 → NP_997960.1 dead end protein 1

See identical proteins and their annotated locations for NP_997960.1

Status: PROVISIONAL

Source sequence(s)

AY225448

UniProtKB/Swiss-Prot

Q4VBK4, Q7T1H5

UniProtKB/TrEMBL

B2GPX0

Related

ENSDARP00000035017.7, ENSDART00000036463.9

Conserved Domains (3) summary

cd12493
Location:138 → 220

RRM2_DND1; RNA recognition motif 2 found in vertebrate dead end protein homolog 1 (DND1)

pfam14709
Location:323 → 403

DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1

cl17169
Location:59 → 136

RRM_SF; RNA recognition motif (RRM) superfamily