bcat-1 Branched-chain-amino-acid aminotransferase, cytosolic [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: bcat-1
Gene description: Branched-chain-amino-acid aminotransferase, cytosolic
Primary source: WormBase:WBGene00001149
Locus tag: CELE_K02A4.1
See related: AllianceGenome:WB:WBGene00001149
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable branched-chain-amino-acid transaminase activity. Involved in branched-chain amino acid catabolic process; embryo development; and nematode larval development. Acts upstream of or within determination of adult lifespan. Located in mitochondrion. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Orthologous to human BCAT1 (branched chain amino acid transaminase 1) and BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See bcat-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (12877480..12880328)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02A4.1 (e-PCR)
- UniSTS:307748

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-isoleucine transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-leucine transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-leucine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-valine transaminase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-amino-acid transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables branched-chain-amino-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoleucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in valine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Branched-chain-amino-acid aminotransferase, cytosolic

NP_510144.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12877480..12880328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077743.5 → NP_510144.1 Branched-chain-amino-acid aminotransferase, cytosolic [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510144.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54688

Conserved Domains (2) summary

PRK13357
Location:57 → 415

PRK13357; branched-chain amino acid aminotransferase; Provisional

cd01557
Location:103 → 404

BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...