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    rrf-2 RNA-directed RNA polymerase [ Caenorhabditis elegans ]

    Gene ID: 173092, updated on 12-Jun-2024

    Summary

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    Gene symbol
    rrf-2
    Gene description
    RNA-directed RNA polymerase
    Locus tag
    CELE_M01G12.12
    See related
    AllianceGenome:WB:WBGene00004509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be part of nuclear RNA-directed RNA polymerase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See rrf-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    21
    Sequence:
    Chromosome: I; NC_003279.8 (12098671..12106112, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Decapping nuclease Neighboring gene Decapping nuclease Neighboring gene Decapping nuclease Neighboring gene Decapping nuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On the role of RNA amplification in dsRNA-triggered gene silencing. Sijen T, et al. Cell, 2001 Nov 16. PMID 11719187
    2. Gene silencing: shrinking the black box of RNAi. Hunter CP. Curr Biol, 2000 Feb 24. PMID 10704407
    3. 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Han T, et al. Proc Natl Acad Sci U S A, 2009 Nov 3. PMID 19846761, Free PMC Article
    4. PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Batista PJ, et al. Mol Cell, 2008 Jul 11. PMID 18571452, Free PMC Article
    5. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Smardon A, et al. Curr Biol, 2000 Feb 24. PMID 10704412

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-dependent RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-dependent RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-dependent RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in RNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear RNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-directed RNA polymerase
    NP_493057.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12098671..12106112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060656.5 → NP_493057.1  RNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFA8
      Conserved Domains (1) summary
      pfam05183
      Location:464 → 1016
      RdRP; RNA dependent RNA polymerase
    Nucleotide Protein
    Heading Accession and Version

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