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    mcd-1 Modifier of cell death [ Caenorhabditis elegans ]

    Gene ID: 175040, updated on 22-May-2024

    Summary

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    Gene symbol
    mcd-1
    Gene description
    Modifier of cell death
    Primary source
    WormBase:WBGene00013096
    Locus tag
    CELE_Y51H1A.6
    See related
    AllianceGenome:WB:WBGene00013096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in nematode larval development; positive regulation of growth rate; and programmed cell death. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mcd-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (13888544..13898463)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Inhibitor of growth protein Neighboring gene Histone deacetylase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway. Luo J, et al. Genetics, 2009 Feb. PMID 19015549, Free PMC Article
    2. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Reddien PW, et al. Genetics, 2007 Apr. PMID 17237514, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Modifier of cell death
    NP_001254412.1
    • Confirmed by transcript evidence
    NP_001254413.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13888544..13898463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267483.3 → NP_001254412.1  Modifier of cell death [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FAS0, B7FAS1

    2. NM_001267484.3 → NP_001254413.1  Modifier of cell death [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FAS0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7FAS0.1

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