FABP6 fatty acid binding protein 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FABP6provided by HGNC
Official Full Name: fatty acid binding protein 6provided by HGNC
Primary source: HGNC:HGNC:3561
See related: Ensembl:ENSG00000170231 MIM:600422; AllianceGenome:HGNC:3561
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
Summary: This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward small intestine (RPKM 820.3) See more
Orthologs: mouse all
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Genomic context

Location:: 5q33.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (160187381..160238722)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (160715939..160767284)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (159614388..159665729)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
Title: Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
Title: Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
Title: Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
Title: Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
Functional suppression of FABP7 significantly inhibited SKRC10 clear cell renal cell carcinoma (ccRCC) cells growth and resulted in a significant reduction of the invasive potential but did not cause growth inhibition of SKRC7 cells. Functional suppression of FABP6 resulted in significant growth inhibition of SKRC7 cells. This is the first report about the complementary role of FABP6 for FABP7 in ccRCC.
Title: Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis.
Title: An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers.
Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR
Title: Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments.
Title: Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding.
show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations
Title: Cooperativity and site selectivity in the ileal lipid binding protein.
Ursodeoxycholic acid induces unique conformational changes in IBABP.
Title: Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S1761 (e-PCR)
- UniSTS:15142

D5S527 (e-PCR)
- UniSTS:148067

AFMA081ZD5 (e-PCR)
- UniSTS:78723

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gastrotropin

Names: GT; fatty acid binding protein 6, ileal; ileal bile acid binding protein; ileal lipid-binding protein; illeal lipid-binding protein; intestinal 15 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029500.1 RefSeqGene

Range

47140..56350

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001040442.1 → NP_001035532.1 gastrotropin isoform 1

See identical proteins and their annotated locations for NP_001035532.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AI208231, BC022489, X90908

Consensus CDS

CCDS43393.1

UniProtKB/Swiss-Prot

P51161

Conserved Domains (1) summary

pfam14651
Location:52 → 177

Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family
NM_001130958.2 → NP_001124430.1 gastrotropin isoform 1

See identical proteins and their annotated locations for NP_001124430.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an additional 5' exon, as compared to variant 1. Both variants 1 and 3 encode the same isoform 1.

Source sequence(s)

DQ132786

Consensus CDS

CCDS43393.1

UniProtKB/Swiss-Prot

P51161

Related

ENSP00000377549.4, ENST00000393980.8

Conserved Domains (1) summary

pfam14651
Location:52 → 177

Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family
NM_001445.3 → NP_001436.1 gastrotropin isoform 2

See identical proteins and their annotated locations for NP_001436.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two 5' exons and has an alternate 5' sequence, and the translation initiation starts from a downstream AUG codon, as compared to variant 1. The encoded protein (isoform 2) is dominant and shorter at the N-terminus, as compared to isoform 1.

Source sequence(s)

X90908

Consensus CDS

CCDS4349.1

UniProtKB/Swiss-Prot

P51161, Q07DR7, Q8TBI3, Q9UGI7

Related

ENSP00000385433.4, ENST00000402432.4

Conserved Domains (1) summary

cl21528
Location:1 → 128

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family