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    Nyap1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304376, updated on 11-Apr-2024

    Summary

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    Symbol
    Nyap1provided by RGD
    Full Name
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1provided by RGD
    Primary source
    RGD:1310964
    See related
    Ensembl:ENSRNOG00000024641 AllianceGenome:RGD:1310964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310964
    Summary
    Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase signaling. Orthologous to human NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 61.0), Kidney (RPKM 14.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nyap1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24591574..24604417)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (18956192..18967624)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22025186..22037428)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481171 Neighboring gene sperm acrosome developmental regulator Neighboring gene TSC22 domain family, member 4 Neighboring gene enoyl CoA hydratase domain containing 2, pseudogene 1 Neighboring gene ArfGAP with FG repeats 2 Neighboring gene insulin receptor substrate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
    Names
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107132.1 → NP_001100602.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

      See identical proteins and their annotated locations for NP_001100602.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J004
      Conserved Domains (2) summary
      pfam15439
      Location:15 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:574 → 835
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24591574..24604417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249144.5 → XP_006249206.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006249206.1

      UniProtKB/TrEMBL
      D3ZDP7
      Related
      ENSRNOP00000031656.5
      Conserved Domains (2) summary
      pfam15439
      Location:15 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:574 → 836
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. XM_017598325.3 → XP_017453814.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

      UniProtKB/TrEMBL
      D3ZDP7
      Conserved Domains (2) summary
      pfam15439
      Location:15 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:574 → 836
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    3. XM_006249147.5 → XP_006249209.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006249209.1

      UniProtKB/TrEMBL
      D3ZDP7
      Conserved Domains (2) summary
      pfam15439
      Location:15 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:574 → 836
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    4. XM_006249145.5 → XP_006249207.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006249207.1

      UniProtKB/TrEMBL
      D3ZDP7
      Conserved Domains (2) summary
      pfam15439
      Location:15 → 413
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:574 → 836
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    Nucleotide Protein Strain
    Heading Accession and Version

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