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    Ankfy1 ankyrin repeat and FYVE domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303292, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ankfy1provided by RGD
    Official Full Name
    ankyrin repeat and FYVE domain containing 1provided by RGD
    Primary source
    RGD:1309598
    See related
    Ensembl:ENSRNOG00000016212 AllianceGenome:RGD:1309598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity and small GTPase binding activity. Predicted to be involved in cytosolic transport; endosomal vesicle fusion; and positive regulation of pinocytosis. Predicted to be located in early endosome; endosome membrane; and macropinosome. Predicted to be part of retromer complex. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 172.5), Lung (RPKM 166.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankfy1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57810781..57882495)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57312246..57383964)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59259955..59331669)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene ribosomal protein L17, pseudogene 5 Neighboring gene cytochrome b5 domain containing 2 Neighboring gene zinc finger ZZ-type and EF-hand domain containing 1 Neighboring gene ribosomal protein S27, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization and chromosomal mapping of a novel human gene, ANKHZN. Kuriyama H, et al. Gene, 2000 Aug 8. PMID 10940552
    2. Molecular cloning of a novel 130-kDa cytoplasmic protein, Ankhzn, containing Ankyrin repeats hooked to a zinc finger motif. Ito K, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092534
    3. RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. Nehru V, et al. Traffic, 2013 Dec. PMID 24102721
    4. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Zhang J, et al. Traffic, 2012 May. PMID 22284051, Free PMC Article
    5. The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. Schnatwinkel C, et al. PLoS Biol, 2004 Sep. PMID 15328530, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rabankyrin-5
    Names
    ankyrin repeat and FYVE domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107018.2 → NP_001100488.2  rabankyrin-5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y6Q8, D4A1J6
      Related
      ENSRNOP00000021816.6, ENSRNOT00000021816.7
      Conserved Domains (8) summary
      smart00225
      Location:69 → 156
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:167 → 235
      BACK; BTB And C-terminal Kelch
      cd00204
      Location:866 → 992
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1101 → 1163
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:61 → 156
      BTB; BTB/POZ domain
      pfam12796
      Location:875 → 969
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:353 → 408
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:726 → 767
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      57810781..57882495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086000.1 → XP_038941928.1  rabankyrin-5 isoform X1

      UniProtKB/TrEMBL
      A6HGG6
      Conserved Domains (6) summary
      PHA03095
      Location:544 → 835
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:391 → 590
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd15728
      Location:943 → 1005
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      sd00045
      Location:568 → 609
      ANK; ANK repeat [structural motif]
      cd18501
      Location:4 → 92
      BACK_ANKFY1_Rank5; BACK (BTB and C-terminal Kelch) domain found in rabankyrin-5 (Rank-5)
      cl39094
      Location:149 → 411
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039086001.2 → XP_038941929.1  rabankyrin-5 isoform X1

      UniProtKB/TrEMBL
      A6HGG6
      Conserved Domains (6) summary
      PHA03095
      Location:544 → 835
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:391 → 590
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd15728
      Location:943 → 1005
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      sd00045
      Location:568 → 609
      ANK; ANK repeat [structural motif]
      cd18501
      Location:4 → 92
      BACK_ANKFY1_Rank5; BACK (BTB and C-terminal Kelch) domain found in rabankyrin-5 (Rank-5)
      cl39094
      Location:149 → 411
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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