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    Nubpl NUBP iron-sulfur cluster assembly factor like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299008, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nubplprovided by RGD
    Official Full Name
    NUBP iron-sulfur cluster assembly factor likeprovided by RGD
    Primary source
    RGD:1307232
    See related
    Ensembl:ENSRNOG00000027444 AllianceGenome:RGD:1307232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307232
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly; mitochondrial respiratory chain complex I assembly; and mitochondrion morphogenesis. Predicted to be located in plasma membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 21. Orthologous to human NUBPL (nucleotide binding protein like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 195.1), Heart (RPKM 57.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nubpl in Genome Data Viewer
    Location:
    6q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75294609..75516603)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69559278..69781254)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72891758..73147837)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 33, pseudogene 1 Neighboring gene D-aminoacyl-tRNA deacylase 2 Neighboring gene tensin-2 pseudogene Neighboring gene ceramide synthase 5, pseudogene 1 Neighboring gene uncharacterized LOC134479384

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Sheftel AD, et al. Mol Cell Biol, 2009 Nov. PMID 19752196, Free PMC Article
    2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    iron-sulfur cluster transfer protein NUBPL
    Names
    iron-sulfur protein NUBPL
    nucleotide binding protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185025.1 → NP_001171954.1  iron-sulfur cluster transfer protein NUBPL precursor

      Status: VALIDATED

      Source sequence(s)
      BF282469, BP486352, CO399813
      UniProtKB/TrEMBL
      D3ZFQ3
      Related
      ENSRNOP00000029049.3, ENSRNOT00000038074.5
      Conserved Domains (2) summary
      COG0489
      Location:13 → 284
      Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
      pfam10609
      Location:65 → 311
      ParA; NUBPL iron-transfer P-loop NTPase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      75294609..75516603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764655.4 → XP_008762877.1  iron-sulfur cluster transfer protein NUBPL isoform X8

      UniProtKB/TrEMBL
      A0A8I6ARC8
      Related
      ENSRNOP00000097251.1
      Conserved Domains (2) summary
      TIGR01969
      Location:17 → 267
      minD_arch; cell division ATPase MinD, archaeal
      pfam10609
      Location:13 → 259
      ParA; NUBPL iron-transfer P-loop NTPase

    2. XM_039111969.2 → XP_038967897.1  iron-sulfur cluster transfer protein NUBPL isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:65 → 231
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_063261670.1 → XP_063117740.1  iron-sulfur cluster transfer protein NUBPL isoform X4

    4. XM_039111970.2 → XP_038967898.1  iron-sulfur cluster transfer protein NUBPL isoform X5

      Conserved Domains (1) summary
      cl38936
      Location:65 → 171
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_063261671.1 → XP_063117741.1  iron-sulfur cluster transfer protein NUBPL isoform X6

    6. XM_063261668.1 → XP_063117738.1  iron-sulfur cluster transfer protein NUBPL isoform X2

    7. XM_063261669.1 → XP_063117739.1  iron-sulfur cluster transfer protein NUBPL isoform X3

    8. XM_063261672.1 → XP_063117742.1  iron-sulfur cluster transfer protein NUBPL isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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