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    mex-1 C3H1-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174836, updated on 19-Jun-2024

    Summary

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    Gene symbol
    mex-1
    Gene description
    C3H1-type domain-containing protein
    Locus tag
    CELE_W03C9.7
    See related
    AllianceGenome:WB:WBGene00003228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in several processes, including embryonic pattern specification; establishment of cell polarity; and formation of primary germ layer. Located in P granule. Is expressed in several structures, including C; D; EMS; germ line; and oocyte. Orthologous to human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mex-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (11968637..11972347)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Ras-related protein Rab-7a Neighboring gene PTK2 Neighboring gene ACB domain-containing protein Neighboring gene BZIP domain-containing protein;Regulator of rDNA transcription 14 Neighboring gene BZIP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular interactions involved in the determination of the early C. elegans embryo. Schnabel R. Mech Dev, 1991 Jun. PMID 1911397
    2. Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5. Pagano JM, et al. J Biol Chem, 2007 Mar 23. PMID 17264081
    3. Effects of chromosomal deficiencies on early cleavage patterning and terminal phenotype in Caenorhabditis elegans embryos. Storfer-Glazer FA, et al. Genetics, 1994 Jun. PMID 8070660, Free PMC Article
    4. An analysis of the response to gut induction in the C. elegans embryo. Goldstein B. Development, 1995 Apr. PMID 7743934
    5. Why does a nematode have an invariant cell lineage? Schnabel R. Semin Cell Dev Biol, 1997 Aug. PMID 15001072

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in formation of primary germ layer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C3H1-type domain-containing protein
    NP_001254325.1
    • Confirmed by transcript evidence
    NP_001254326.1
    • Confirmed by transcript evidence
    NP_001391110.1
    • Confirmed by transcript evidence
    NP_001391129.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11968637..11972347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001404252.1 → NP_001391110.1  C3H1-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QD38

    2. NM_001267396.4 → NP_001254325.1  C3H1-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECB9
      Conserved Domains (1) summary
      pfam00642
      Location:139 → 165
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    3. NM_001404254.1 → NP_001391129.1  C3H1-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QB40

    4. NM_001267397.3 → NP_001254326.1  C3H1-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2HJZ1
    Nucleotide Protein
    Heading Accession and Version

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