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    x16 x16 splicing factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33967, updated on 19-Jun-2024

    Summary

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    Official Symbol
    x16provided by FlyBase
    Official Full Name
    x16 splicing factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028554
    Locus tag
    Dmel_CG10203
    See related
    AllianceGenome:FB:FBgn0028554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2/30; 9G8; anon-WO0118547.78; CG10203; d9G8; Dmel\CG10203; dx16; Dx16; dxl6; Dxl6; l(2)k00230; RBP1-like; TN166; X16; X16/9G8; xl6; Xl6; XL6
    Summary
    Enables mRNA binding activity. Involved in RNA splicing and regulation of RNA metabolic process. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including ectoderm; embryonic/larval nervous system; extended germ band embryo; imaginal disc; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including SRSF7 (serine and arginine rich splicing factor 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See x16 in Genome Data Viewer
    Location:
    27C4-27C4; 2-23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6914301..6920210, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6914301..6920210, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit F Neighboring gene Rat1 5'-3' exoribonuclease Neighboring gene ncRNA Neighboring gene Wee1 kinase Neighboring gene uncharacterized protein Neighboring gene nop5 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 27C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of RNA binding sequences of Drosophila SR protein DX16. Yuan L, et al. Mol Cell Biochem, 2007 Aug. PMID 17345156
    2. DX16 is a novel SR protein phosphorylated by DOA. Wan Y, et al. Mol Cell Biochem, 2008 Jan. PMID 17828581
    3. Restricted expression and subnuclear localization of the Drosophila gene Dnop5, a member of the Nop/Sik family of the conserved rRNA processing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640717
    4. The control of lipid metabolism by mRNA splicing in Drosophila. Gingras RM, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333419, Free PMC Article
    5. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. Ritson GP, et al. J Neurosci, 2010 Jun 2. PMID 20519548, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    x16 splicing factor
    Names
    CG10203-PA
    CG10203-PB
    x16-PA
    x16-PB
    xl6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6914301..6920210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273239.2 → NP_001260168.1  x16 splicing factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260168.1

      Status: REVIEWED

      Conserved Domains (3) summary
      smart00343
      Location:116 → 132
      ZnF_C2HC; zinc finger
      COG0724
      Location:1 → 82
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12373
      Location:9 → 81
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

    2. NM_164718.2 → NP_723226.1  x16 splicing factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723226.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PC85, Q9V3V0
      Related
      FBpp0078996
      Conserved Domains (2) summary
      COG0724
      Location:1 → 82
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12373
      Location:9 → 81
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC85 M9PC85
    Q9V3V0 Q9V3V0

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