Rim Rab3 interacting molecule [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rimprovided by FlyBase
Official Full Name: Rab3 interacting moleculeprovided by FlyBase
Primary source: FLYBASE:FBgn0053547
Locus tag: Dmel_CG33547
See related: AllianceGenome:FB:FBgn0053547
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33547; CG7301; CG7305; CG7321; dm-Rim; Dmel\CG33547; DmRIM; DRIM; rim; RIM; rim-1; UNC-10/RIM
Summary: Predicted to enable small GTPase binding activity. Involved in clustering of voltage-gated calcium channels; neuromuscular synaptic transmission; and regulation of synaptic plasticity. Located in cytoskeleton of presynaptic active zone. Is expressed in adult head. Human ortholog(s) of this gene implicated in cone-rod dystrophy 7. Orthologous to several human genes including RIMS1 (regulating synaptic membrane exocytosis 1) and RIMS2 (regulating synaptic membrane exocytosis 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 90C8-90C10; 3-61 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17872748..17916578, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13698470..13742300, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.
Title: The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.
RIM-binding protein couples synaptic vesicle recruitment to release sites.
Title: RIM-binding protein couples synaptic vesicle recruitment to release sites.
RIM-binding protein stabilizes synaptic efficacy and homeostasis through control of presynaptic calcium influx.
Title: RIM-binding protein links synaptic homeostasis to the stabilization and replenishment of high release probability vesicles.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-ion regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in clustering of voltage-gated calcium channels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoskeleton of presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton of presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rab3 interacting molecule

Names: CG33547-PAA; CG33547-PF; CG33547-PK; CG33547-PP; CG33547-PQ; CG33547-PR; CG33547-PS; CG33547-PT; CG33547-PU; CG33547-PV; CG33547-PW; CG33547-PX; CG33547-PY; CG33547-PZ; Rab3-interacting molecule; Rim-PAA; Rim-PF; Rim-PK; Rim-PP; Rim-PQ; Rim-PR; Rim-PS; Rim-PT; Rim-PU; Rim-PV; Rim-PW; Rim-PX; Rim-PY; Rim-PZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

17872748..17916578 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260237.2 → NP_001247166.2 Rab3 interacting molecule, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247166.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7E1

Conserved Domains (4) summary

cd04028
Location:1790 → 1932

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260238.2 → NP_001247167.2 Rab3 interacting molecule, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247167.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7E7

Conserved Domains (4) summary

cd04028
Location:1800 → 1941

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001275758.1 → NP_001262687.1 Rab3 interacting molecule, isoform AA [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262687.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG75

Conserved Domains (2) summary

cd04028
Location:1217 → 1358

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260243.2 → NP_001247172.2 Rab3 interacting molecule, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247172.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7F3

Conserved Domains (2) summary

cd04028
Location:1258 → 1399

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001014630.4 → NP_001014630.3 Rab3 interacting molecule, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014630.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VEE5

Conserved Domains (4) summary

cd04028
Location:1790 → 1931

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260232.2 → NP_001247161.2 Rab3 interacting molecule, isoform X [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247161.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7E1

Conserved Domains (4) summary

cd04028
Location:1790 → 1932

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260241.2 → NP_001247170.2 Rab3 interacting molecule, isoform V [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247170.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K679

Conserved Domains (4) summary

cd04028
Location:1800 → 1942

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260240.2 → NP_001247169.2 Rab3 interacting molecule, isoform W [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247169.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K742, V5M054

Conserved Domains (4) summary

cd04028
Location:2430 → 2572

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260231.1 → NP_001247160.1 Rab3 interacting molecule, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247160.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6B1, V5M2P5

Conserved Domains (4) summary

cd04028
Location:2633 → 2777

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260234.1 → NP_001247163.1 Rab3 interacting molecule, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247163.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6M2, V5M2P5

Conserved Domains (4) summary

cd04028
Location:2633 → 2775

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260239.1 → NP_001247168.1 Rab3 interacting molecule, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247168.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6M2, V5M2P5

Conserved Domains (4) summary

cd04028
Location:2633 → 2775

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:1148 → 1272

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:817 → 919

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260235.2 → NP_001247164.2 Rab3 interacting molecule, isoform Y [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247164.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K677

Conserved Domains (4) summary

cd04028
Location:1480 → 1621

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:838 → 962

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:507 → 609

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260233.2 → NP_001247162.2 Rab3 interacting molecule, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247162.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6L8

Conserved Domains (4) summary

cd04028
Location:1490 → 1631

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:838 → 962

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:507 → 609

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily
NM_001260242.2 → NP_001247171.2 Rab3 interacting molecule, isoform Z [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247171.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6B7

Conserved Domains (4) summary

cd04028
Location:1490 → 1632

C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

cd04031
Location:838 → 962

C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins

cd00992
Location:507 → 609

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl22851
Location:8 → 126

PHD_SF; PHD finger superfamily

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K677		A0A0B4K677
A0A0B4K679		A0A0B4K679
A0A0B4K6B1		A0A0B4K6B1
A0A0B4K6B7		A0A0B4K6B7
A0A0B4K6L8		A0A0B4K6L8
A0A0B4K6M2		A0A0B4K6M2
A0A0B4K742		A0A0B4K742
A0A0B4K7E1		A0A0B4K7E1
A0A0B4K7E7		A0A0B4K7E7
A0A0B4K7F3		A0A0B4K7F3
A0A0B4KG75		A0A0B4KG75
Q95T36		Q95T36
Q9VEE5		Q9VEE5