U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Defb21 defensin beta 21 [ Mus musculus (house mouse) ]

    Gene ID: 403172, updated on 8-Feb-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Defb21provided by MGI
    Official Full Name
    defensin beta 21provided by MGI
    Primary source
    MGI:MGI:2684967
    See related
    Ensembl:ENSMUSG00000056544 AllianceGenome:MGI:2684967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm121; 4930525K10Rik
    Summary
    Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-negative bacterium; and membrane disruption in other organism. Is expressed in forelimb bud. Orthologous to human DEFB118 (defensin beta 118). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 67.6) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Defb21 in Genome Data Viewer
    Location:
    2 H1; 2 75.31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152414663..152416864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152572743..152574944)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene defensin beta 29 Neighboring gene predicted gene 14161 Neighboring gene STARR-seq mESC enhancer starr_06064 Neighboring gene predicted gene, 17416 Neighboring gene defensin beta 19 Neighboring gene defensin beta 45

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
    2. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables membrane destabilizing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-defensin 118

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379477.1 → NP_001366406.1  beta-defensin 118 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5 UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845162
      UniProtKB/TrEMBL
      Q2F9P8, Q8C5Z4
      Conserved Domains (1) summary
      pfam13841
      Location:33 → 62
      Defensin_beta_2; Beta defensin

    2. NM_207276.3 → NP_997159.1  beta-defensin 118 precursor

      See identical proteins and their annotated locations for NP_997159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845162
      Consensus CDS
      CCDS16890.1
      UniProtKB/TrEMBL
      Q2F9P8, Q8C5Z4
      Related
      ENSMUSP00000065102.3, ENSMUST00000070722.3
      Conserved Domains (1) summary
      pfam13841
      Location:33 → 62
      Defensin_beta_2; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152414663..152416864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous