Pelp1 proline, glutamate and leucine rich protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pelp1provided by RGD
Official Full Name: proline, glutamate and leucine rich protein 1provided by RGD
Primary source: RGD:1306320
See related: Ensembl:ENSRNOG00000019268 AllianceGenome:RGD:1306320
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306320
Summary: Predicted to enable several functions, including ATPase binding activity; SUMO binding activity; and protein N-terminus binding activity. Predicted to be involved in cellular response to estrogen stimulus and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of MLL1 complex. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 57.2), Adrenal (RPKM 54.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55593444..55610478, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55094798..55111833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56988076..57005111, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pelp1 may be a key regulator of proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.
Title: Temporal expression of Pelp1 during proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells.
Estradiol treatment of PDLFCs induced PELP1 protein level compared to untreated cells.
Title: Increased PELP1 expression in rat periodontal ligament tissue in response to estrogens treatment.
MNAR/PELP1 is expressed in key neural tissues of the rat brain that are known targets of steroid action; its expression is primarily neuronal; and MNAR/PELP1-ir is strongly colocalized in ER-alpha, but not GnRH neurons in rodent brain.
Title: Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pelp1 (e-PCR), detects polymorphism
- UniSTS:498759

RH129345 (e-PCR)
- UniSTS:212652

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of euchromatin	ISO Inferred from Sequence Orthology more info
part_of euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proline-, glutamic acid- and leucine-rich protein 1

Names: modulator of non-genomic activity of estrogen receptor; modulator of nongenomic activity of estrogen receptor; proline, glutamic acid and leucine rich protein 1; proline-, glutamic acid-, leucine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.