Smc1b structural maintenance of chromosomes 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smc1bprovided by RGD
Official Full Name: structural maintenance of chromosomes 1Bprovided by RGD
Primary source: RGD:1308791
See related: Ensembl:ENSRNOG00000032570 AllianceGenome:RGD:1308791
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smc1l2
Summary: Predicted to enable DNA binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to act upstream of or within meiotic cell cycle. Predicted to be located in chromosome, centromeric region; cytosol; and nuclear lumen. Predicted to be part of nuclear meiotic cohesin complex. Predicted to be active in nucleus. Orthologous to human SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 197.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (118060898..118122683, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (116180987..116242778, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (125966480..126028287, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sister chromatid cohesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lateral element	ISO Inferred from Sequence Orthology more info
part_of meiotic cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of meiotic cohesin complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: structural maintenance of chromosomes protein 1B

Names: SMC; structural maintenace of chromosomes 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130498.1 → NP_001123970.1 structural maintenance of chromosomes protein 1B

See identical proteins and their annotated locations for NP_001123970.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A6HTD3, D3ZE73

Related

ENSRNOP00000043834.3, ENSRNOT00000044883.5

Conserved Domains (4) summary

cd03275
Location:4 → 148

ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins

smart00968
Location:513 → 628

SMC_hinge; SMC proteins Flexible Hinge Domain

COG1196
Location:3 → 1199

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19219
Location:421 → 492

DUF342; Protein of unknown function (DUF342)