Dvl1 dishevelled segment polarity protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dvl1provided by MGI
Official Full Name: dishevelled segment polarity protein 1provided by MGI
Primary source: MGI:MGI:94941
See related: Ensembl:ENSMUSG00000029071 AllianceGenome:MGI:94941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dvl; mKIAA4029
Summary: The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in ovary adult (RPKM 66.4), duodenum adult (RPKM 56.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 87.61 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155931829..155943760)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155847402..155859303)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain is stabilized upon CXXC finger 5 protein (CXXC5) binding.
Title: Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5.
Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.
Title: Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways.
The interaction of Dvl1 with Syt-1, which is regulated by Wnts, modulates neurotransmitter release.
Title: Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
High disheveled expression is associated with pulmonary fibrosis.
Title: Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process.
findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced by selenium deficiency
Title: Dishevelled-1 (Dvl-1) protein: a potential participant of oxidative stress induced by selenium deficiency.
These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1, in the formation of synapses on cortical interneuron dendrites.
Title: Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons.
we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb .
Title: Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.
Fuzzy appears to control subcellular localization of the core PCP protein Dishevelled, recruiting it to Rab8-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP signaling
Title: The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium.
A Wnt5a--> Dvl PCP signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
Title: Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.
Findings indicate that Daple interacts with Dishevelled to direct the Dishevelled/protein kinase lambda protein complex to activate Rac, which in turn mediates the non-canonical Wnt signalling pathway required for cell migration.
Title: The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dvl (e-PCR), detects polymorphism
- UniSTS:142878

Dvl (e-PCR), detects polymorphism
- UniSTS:142879

Dvl1 (e-PCR), detects polymorphism
- UniSTS:532276

Dvl1 (e-PCR), detects polymorphism
- UniSTS:508377

Dvl1 (e-PCR), detects polymorphism
- UniSTS:532451

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within convergent extension involved in neural plate elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in organogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in organogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasmic microtubule organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytoplasmic microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart looping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in planar cell polarity pathway involved in neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to microtubule	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein stabilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle acetylcholine-gated channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: segment polarity protein dishevelled homolog DVL-1

Names: DSH homolog 1; dishevelled, dsh homolog 1; dishevelled-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356381.1 → NP_001343310.1 segment polarity protein dishevelled homolog DVL-1 isoform 2

Status: REVIEWED

Source sequence(s)

AL670236, BC088987, U10115

Related

ENSMUST00000143457.8

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd04438
Location:417 → 499

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:251 → 336

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:503 → 571

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
NM_010091.5 → NP_034221.3 segment polarity protein dishevelled homolog DVL-1 isoform 1

See identical proteins and their annotated locations for NP_034221.3

Status: REVIEWED

Source sequence(s)

AL670236, BC088987, U10115

Consensus CDS

CCDS19045.1

UniProtKB/Swiss-Prot

P51141, Q3U2D3, Q60868

Related

ENSMUSP00000030948.10, ENSMUST00000030948.16

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd04438
Location:417 → 499

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam00595
Location:251 → 336

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:503 → 685

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

155931829..155943760

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538523.4 → XP_006538586.1 segment polarity protein dishevelled homolog DVL-1 isoform X6

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd00992
Location:249 → 336

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:431 → 513

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:517 → 585

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
XM_006538518.4 → XP_006538581.1 segment polarity protein dishevelled homolog DVL-1 isoform X1

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd00992
Location:249 → 336

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:431 → 513

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:517 → 699

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
XM_006538519.4 → XP_006538582.1 segment polarity protein dishevelled homolog DVL-1 isoform X2

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd00992
Location:249 → 336

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:406 → 488

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:492 → 674

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
XM_006538520.5 → XP_006538583.1 segment polarity protein dishevelled homolog DVL-1 isoform X3

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd00992
Location:249 → 336

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:392 → 474

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:478 → 660

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
XM_006538521.4 → XP_006538584.1 segment polarity protein dishevelled homolog DVL-1 isoform X4

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd00992
Location:249 → 336

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:366 → 448

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:452 → 634

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
XM_006538522.5 → XP_006538585.1 segment polarity protein dishevelled homolog DVL-1 isoform X5

Conserved Domains (5) summary

smart00021
Location:1 → 85

DAX; Domain present in Dishevelled and axin

cd00992
Location:249 → 336

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:431 → 513

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:90 → 247

Dishevelled; Dishevelled specific domain

pfam12316
Location:517 → 587

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001302342.1: Suppressed sequence

Description

NM_001302342.1: This RefSeq was removed because currently there is insufficient support for the transcript.