Dohh deoxyhypusine hydroxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dohhprovided by RGD
Official Full Name: deoxyhypusine hydroxylaseprovided by RGD
Primary source: RGD:1304783
See related: Ensembl:ENSRNOG00000004259 AllianceGenome:RGD:1304783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304783
Summary: Predicted to enable deoxyhypusine monooxygenase activity and iron ion binding activity. Predicted to be involved in peptidyl-lysine modification to peptidyl-hypusine. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 135.6), Brain (RPKM 106.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (8972202..8977025, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8321466..8326305, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11191127..11195971, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables deoxyhypusine monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyhypusine monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables deoxyhypusine monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables deoxyhypusine monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptidyl-lysine modification to peptidyl-hypusine	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: deoxyhypusine hydroxylase

Names: deoxyhypusine dioxygenase; deoxyhypusine hydroxylase/monooxygenase; deoxyhypusine monooxygenase

NP_001020177.1

EC 1.14.99.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025006.2 → NP_001020177.1 deoxyhypusine hydroxylase

See identical proteins and their annotated locations for NP_001020177.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q5PPJ4

UniProtKB/TrEMBL

A0A8L2Q272

Related

ENSRNOP00000093565.1, ENSRNOT00000112038.1

Conserved Domains (3) summary

smart00567
Location:52 → 80

EZ_HEAT; E-Z type HEAT repeats

pfam13646
Location:7 → 96

HEAT_2; HEAT repeats

sd00044
Location:39 → 67

HEAT; HEAT repeat [structural motif]