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    Ppp4r1 protein phosphatase 4, regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140943, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp4r1provided by RGD
    Official Full Name
    protein phosphatase 4, regulatory subunit 1provided by RGD
    Primary source
    RGD:619798
    See related
    Ensembl:ENSRNOG00000013733 AllianceGenome:RGD:619798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pp4r1
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase 4 complex. Orthologous to human PPP4R1 (protein phosphatase 4 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 358.8), Lung (RPKM 163.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp4r1 in Genome Data Viewer
    Location:
    9q37
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (112836950..112897490)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (105391271..105450626)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (113515312..113573308)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RAB31, member RAS oncogene family Neighboring gene uncharacterized LOC102552808 Neighboring gene transfer RNA leucine (anticodon AAG) 17 Neighboring gene ralA binding protein 1 Neighboring gene ferritin light chain 1, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells. Wada T, et al. J Am Soc Nephrol, 2001 Dec. PMID 11729228
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080907.2 → NP_543183.1  serine/threonine-protein phosphatase 4 regulatory subunit 1

      See identical proteins and their annotated locations for NP_543183.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061726
      UniProtKB/Swiss-Prot
      Q8VI02
      UniProtKB/TrEMBL
      F1LRK9
      Related
      ENSRNOP00000061977.3, ENSRNOT00000066793.4
      Conserved Domains (2) summary
      pfam15017
      Location:432 → 471
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:133 → 157
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      112836950..112897490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082982.2 → XP_038938910.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACS7, A0A8I6AX20, A6JRC4, A6JRC6
      Related
      ENSRNOP00000090902.1
      Conserved Domains (3) summary
      PRK07764
      Location:315 → 489
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:407 → 442
      WRNPLPNID; Putative WW-binding domain and destruction box

    2. XM_039082984.2 → XP_038938912.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACS7, A0A8I6AX20, A6JRC4, A6JRC6
      Conserved Domains (3) summary
      PRK07764
      Location:315 → 489
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:407 → 442
      WRNPLPNID; Putative WW-binding domain and destruction box

    3. XM_063266612.1 → XP_063122682.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X7

    4. XM_039082980.2 → XP_038938908.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X4

      UniProtKB/TrEMBL
      F1LRK9
      Conserved Domains (3) summary
      PRK07764
      Location:341 → 515
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:116 → 140
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:433 → 468
      WRNPLPNID; Putative WW-binding domain and destruction box

    5. XM_039082978.2 → XP_038938906.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AX20, A6JRC4
      Conserved Domains (3) summary
      PRK07764
      Location:343 → 517
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:118 → 142
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:435 → 470
      WRNPLPNID; Putative WW-binding domain and destruction box

    6. XM_039082979.2 → XP_038938907.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AX20, A6JRC4
      Conserved Domains (3) summary
      PRK07764
      Location:342 → 516
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:117 → 141
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:434 → 469
      WRNPLPNID; Putative WW-binding domain and destruction box

    7. XM_039082981.2 → XP_038938909.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AX20, A6JRC4
      Conserved Domains (3) summary
      PRK07764
      Location:331 → 505
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:106 → 130
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:423 → 458
      WRNPLPNID; Putative WW-binding domain and destruction box

    8. XM_039082977.2 → XP_038938905.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AX20, A6JRC4
      Conserved Domains (3) summary
      PRK07764
      Location:348 → 522
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:123 → 147
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:440 → 475
      WRNPLPNID; Putative WW-binding domain and destruction box

    9. XM_039082985.2 → XP_038938913.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACS7, A0A8I6AX20, A6JRC4, A6JRC6
      Conserved Domains (3) summary
      PRK07764
      Location:315 → 489
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:407 → 442
      WRNPLPNID; Putative WW-binding domain and destruction box

    10. XM_039082983.2 → XP_038938911.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACS7, A0A8I6AX20, A6JRC4, A6JRC6
      Related
      ENSRNOP00000097964.1
      Conserved Domains (3) summary
      PRK07764
      Location:315 → 489
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00044
      Location:90 → 114
      HEAT; HEAT repeat [structural motif]
      pfam15017
      Location:407 → 442
      WRNPLPNID; Putative WW-binding domain and destruction box

    RNA

    1. XR_010054561.1 RNA Sequence

    2. XR_010054562.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI02.1 GenPept UniProtKB/Swiss-Prot:Q8VI02

    Gene LinkOut

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