Zbtb39 zinc finger and BTB domain containing 39 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbtb39provided by RGD
Official Full Name: zinc finger and BTB domain containing 39provided by RGD
Primary source: RGD:1306532
See related: Ensembl:ENSRNOG00000004306 AllianceGenome:RGD:1306532
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306532
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human ZBTB39 (zinc finger and BTB domain containing 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 61.5), Adrenal (RPKM 53.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65462255..65469806)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63576998..63584549)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71036581..71044057)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129996 (e-PCR)
- UniSTS:213284

RH133901 (e-PCR)
- UniSTS:217184

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130537.2 → NP_001124009.1 zinc finger and BTB domain-containing protein 39

See identical proteins and their annotated locations for NP_001124009.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6ARN3, A6HQX1

Related

ENSRNOP00000091432.1, ENSRNOT00000094578.1

Conserved Domains (5) summary

sd00017
Location:606 → 626

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18224
Location:4 → 126

BTB_POZ_ZBTB39; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39)

pfam00096
Location:604 → 626

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:618 → 642

zf-H2C2_2; Zinc-finger double domain

cl00040
Location:620 → 667

C1; protein kinase C conserved region 1 (C1 domain) superfamily