Mos MOS proto-oncogene, serine/threonine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mosprovided by RGD
Official Full Name: MOS proto-oncogene, serine/threonine kinaseprovided by RGD
Primary source: RGD:3103
See related: Ensembl:ENSRNOG00000008567 AllianceGenome:RGD:3103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; microtubule cytoskeleton organization; and negative regulation of metaphase/anaphase transition of meiotic cell cycle. Predicted to act upstream of or within regulation of meiotic nuclear division. Located in cytosol. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (21657549..21658856, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (16859957..16861264, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (16746085..16747392, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NGF, by enhancing Mos in late spermatocytes, is one of the intra-testicular factors which adjusts the number of round spermatids that can be supported by Sertoli cells
Title: Cytostatic factor proteins are present in male meiotic cells and beta-nerve growth factor increases mos levels in rat late spermatocytes.
Definitive expression of c-mos in late meiotic prophase leads to phosphorylation of a 34 kda protein in cultured rat spermatocytes
Title: Definitive expression of c-mos in late meiotic prophase leads to phosphorylation of a 34 kda protein in cultured rat spermatocytes.
cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes
Title: cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of meiotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in establishment of meiotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of meiotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in meiotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in meiotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene serine/threonine-protein kinase mos

Names: Moloney murine sarcoma viral (v-mos) oncogene homolog; Moloney sarcoma oncogene; c-mos; oocyte maturation factor mos; proto-oncogene c-Mos; v-mos moloney murine sarcoma viral oncogene homolog

NP_064487.3

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020102.4 → NP_064487.3 proto-oncogene serine/threonine-protein kinase mos

See identical proteins and their annotated locations for NP_064487.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P00539

UniProtKB/TrEMBL

A6JFL8, M0R4F9

Related

ENSRNOP00000064243.1, ENSRNOT00000011602.6

Conserved Domains (2) summary

smart00220
Location:64 → 331

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13979
Location:58 → 329

STKc_Mos; Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos