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    Slc44a1 solute carrier family 44 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85254, updated on 2-May-2024

    Summary

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    Official Symbol
    Slc44a1provided by RGD
    Official Full Name
    solute carrier family 44 member 1provided by RGD
    Primary source
    RGD:621426
    See related
    Ensembl:ENSRNOG00000055089 AllianceGenome:RGD:621426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ctl1; Cdw92
    Summary
    Enables choline transmembrane transporter activity. Involved in choline transport and transmembrane transport. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SLC44A1 (solute carrier family 44 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 107.8), Adrenal (RPKM 103.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc44a1 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (72857323..73037279)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (68061941..68241912)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (70243643..70424115)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551410 Neighboring gene uncharacterized LOC120102879 Neighboring gene ribosomal protein S23, pseudogene 8 Neighboring gene uncharacterized LOC102551474 Neighboring gene chromobox protein homolog 3-like Neighboring gene fibronectin type III and SPRY domain containing 1-like Neighboring gene fukutin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT. Lee NY, et al. Placenta, 2009 Apr. PMID 19246089
    2. Na(+)-independent choline transport in rat retinal capillary endothelial cells. Tomi M, et al. Neurochem Res, 2007 Nov. PMID 17520363
    3. Molecular and functional characterization of an Na+-independent choline transporter in rat astrocytes. Inazu M, et al. J Neurochem, 2005 Sep. PMID 16000150
    4. Changes in mRNA for choline transporter-like protein following facial nerve transection. Che YH, et al. Brain Res Mol Brain Res, 2002 May 30. PMID 12007839
    5. Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro. Heffernan C, et al. J Biol Chem, 2017 Mar 17. PMID 28119456, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC44A1 acts as a choline transporter both in the plasma membrane and in the mitochondria. Novel aspects of choline transport regulation in the muscle, nervous system, and cancer are reviewed. Review.
      Title: Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1.
    2. CTL1-deficient Schwann cells are significantly impaired in their ability to myelinate neurites in vitro.
      Title: Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro.
    3. Choline transport via choline transporter-like protein 1 in conditionally immortalized syncytiotrophoblast cell lines TR-TBT.
      Title: Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT.
    4. Although rat CTL1 expression is associated with the choline uptake, CTL1 does not play a major role in the choline uptake at the inner blood-retinal barrier.
      Title: Na(+)-independent choline transport in rat retinal capillary endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables choline transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ethanolamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ethanolamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables organic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quaternary ammonium group transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables salt transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in choline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in choline transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in choline transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in choline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ethanolamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ethanolamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanolamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in organic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quaternary ammonium group transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    choline transporter-like protein 1
    Names
    CDW92 antigen
    solute carrier family 44 (choline transporter), member 1
    transporter-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033852.1 → NP_001029024.1  choline transporter-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001029024.1

      Status: VALIDATED

      Source sequence(s)
      AJ420809, BM391692, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      UniProtKB/TrEMBL
      A0A0G2K0P8, A6KDP2
      Related
      ENSRNOP00000071535.1, ENSRNOT00000083983.2
      Conserved Domains (1) summary
      pfam04515
      Location:292 → 603
      Choline_transpo; Plasma-membrane choline transporter

    2. NM_053492.4 → NP_445944.2  choline transporter-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_445944.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      UniProtKB/TrEMBL
      A0A0G2K7R8, A6KDP1
      Related
      ENSRNOP00000074317.1, ENSRNOT00000082108.2
      Conserved Domains (1) summary
      pfam04515
      Location:292 → 603
      Choline_transpo; Plasma-membrane choline transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      72857323..73037279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763717.3 → XP_008761939.1  choline transporter-like protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      Conserved Domains (1) summary
      pfam04515
      Location:297 → 608
      Choline_transpo; Plasma-membrane choline transporter

    2. XM_008763716.4 → XP_008761938.1  choline transporter-like protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      Conserved Domains (1) summary
      pfam04515
      Location:297 → 608
      Choline_transpo; Plasma-membrane choline transporter

    3. XM_039110883.2 → XP_038966811.1  choline transporter-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      Conserved Domains (1) summary
      pfam04515
      Location:298 → 608
      Choline_transpo; Plasma-membrane choline transporter

    4. XM_039110884.2 → XP_038966812.1  choline transporter-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      Conserved Domains (1) summary
      pfam04515
      Location:293 → 603
      Choline_transpo; Plasma-membrane choline transporter

    5. XM_039110885.2 → XP_038966813.1  choline transporter-like protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q8VII6, Q9JJZ7
      Conserved Domains (1) summary
      pfam04515
      Location:256 → 566
      Choline_transpo; Plasma-membrane choline transporter

    6. XM_039110886.2 → XP_038966814.1  choline transporter-like protein 1 isoform X6

      Conserved Domains (1) summary
      pfam04515
      Location:68 → 378
      Choline_transpo; Plasma-membrane choline transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VII6.1 GenPept UniProtKB/Swiss-Prot:Q8VII6

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