Trim11 tripartite motif-containing 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim11provided by RGD
Official Full Name: tripartite motif-containing 11provided by RGD
Primary source: RGD:1305448
See related: Ensembl:ENSRNOG00000002915 AllianceGenome:RGD:1305448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein domain specific binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of viral transcription; and regulation of viral entry into host cell. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TRIM11 (tripartite motif containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 95.7), Thymus (RPKM 93.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44255019..44270711)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (43758299..43771138)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45322199..45335030)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of AIM2 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM11

Names: RING-type E3 ubiquitin transferase TRIM11; tripartite motif protein 11; tripartite motif-containing protein 11

NP_001386475.1

EC 2.3.2.27

XP_038942233.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399546.1 → NP_001386475.1 E3 ubiquitin-protein ligase TRIM11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

B1H278

Related

ENSRNOP00000039974.5, ENSRNOT00000047268.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

44255019..44270711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086305.2 → XP_038942233.1 E3 ubiquitin-protein ligase TRIM11 isoform X1

Conserved Domains (4) summary

COG1196
Location:132 → 189

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00162
Location:16 → 56

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl00034
Location:90 → 131

Bbox_SF; B-box-type zinc finger superfamily

cl17238
Location:13 → 57

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108276.1: Suppressed sequence

Description

NM_001108276.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.