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    Ankrd9 ankyrin repeat domain 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314457, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ankrd9provided by RGD
    Official Full Name
    ankyrin repeat domain 9provided by RGD
    Primary source
    RGD:1307662
    See related
    Ensembl:ENSRNOG00000008056 AllianceGenome:RGD:1307662
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in cellular copper ion homeostasis; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ANKRD9 (ankyrin repeat domain 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 203.4), Testes (RPKM 137.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd9 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (135827355..135830002, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130001914..130008792, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (135409698..135412552, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 839 Neighboring gene cyclin-dependent kinase 2-interacting protein Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene uncharacterized LOC134479258 Neighboring gene uncharacterized LOC134479478 Neighboring gene REST corepressor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular copper ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012112.1 → NP_001012112.1  ankyrin repeat domain-containing protein 9

      See identical proteins and their annotated locations for NP_001012112.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079192
      UniProtKB/TrEMBL
      A6KBP4, Q6P755
      Related
      ENSRNOP00000010610.3, ENSRNOT00000010610.6
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      135827355..135830002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764937.3 → XP_008763159.1  ankyrin repeat domain-containing protein 9 isoform X1

      See identical proteins and their annotated locations for XP_008763159.1

      UniProtKB/TrEMBL
      A6KBP4, Q6P755
      Related
      ENSRNOP00000092911.1
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    2. XM_017594189.3 → XP_017449678.1  ankyrin repeat domain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A6KBP4, Q6P755
      Related
      ENSRNOP00000094725.1
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)

    3. XM_039112416.2 → XP_038968344.1  ankyrin repeat domain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A6KBP4, Q6P755
      Conserved Domains (2) summary
      sd00045
      Location:157 → 188
      ANK; ANK repeat [structural motif]
      pfam13857
      Location:156 → 197
      Ank_5; Ankyrin repeats (many copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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