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    Or4c58 olfactory receptor family 4 subfamily C member 58 [ Mus musculus (house mouse) ]

    Gene ID: 18347, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Or4c58provided by MGI
    Official Full Name
    olfactory receptor family 4 subfamily C member 58provided by MGI
    Primary source
    MGI:MGI:1333765
    See related
    Ensembl:ENSMUSG00000075072 AllianceGenome:MGI:1333765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3; IC3; Olfr48; MOR232-5
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See Or4c58 in Genome Data Viewer
    Location:
    2 E1; 2 50.13 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (89674410..89675315, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (89844066..89844971, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily C member 12B Neighboring gene olfactory receptor family 4 subfamily A member 47 Neighboring gene olfactory receptor family 4 subfamily C member 10B Neighboring gene STARR-seq mESC enhancer starr_05078 Neighboring gene olfactory receptor family 4 subfamily C member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of ligands for olfactory receptors by functional expression of a receptor library. Krautwurst D, et al. Cell, 1998 Dec 23. PMID 9875846
    2. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Kirchhof P, et al. Circ Cardiovasc Genet, 2011 Apr. PMID 21282332
    3. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    4. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    5. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor family 4 subfamily C member 58
    Names
    GA_x6K02T2Q125-51285881-51284976
    olfactory receptor 48
    olfactory receptor MOR232-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010990.1 → NP_035120.1  olfactory receptor family 4 subfamily C member 58

      See identical proteins and their annotated locations for NP_035120.1

      Status: PROVISIONAL

      Source sequence(s)
      AY073112
      Consensus CDS
      CCDS16395.1
      UniProtKB/TrEMBL
      Q8VGN4
      Related
      ENSMUSP00000097350.2, ENSMUST00000099762.2
      Conserved Domains (2) summary
      pfam00001
      Location:36 → 282
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:26 → 296
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      89674410..89675315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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