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    Scarf2 scavenger receptor class F, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287949, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Scarf2provided by RGD
    Official Full Name
    scavenger receptor class F, member 2provided by RGD
    Primary source
    RGD:1306013
    See related
    Ensembl:ENSRNOG00000000288 AllianceGenome:RGD:1306013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable scavenger receptor activity. Predicted to be involved in endocytosis. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Human ortholog(s) of this gene implicated in Van den Ende-Gupta syndrome. Orthologous to human SCARF2 (scavenger receptor class F member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 141.4), Uterus (RPKM 59.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scarf2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96680237..96691686, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83175956..83187415, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87722350..87733734)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein FAM246A-like Neighboring gene carbonic anhydrase 15 Neighboring gene kelch-like family member 22 Neighboring gene large ribosomal subunit protein eL31-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii J, et al. J Biol Chem, 2002 Oct 18. PMID 12154095
    2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor class F member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105864.1 → NP_001099334.1  scavenger receptor class F member 2 precursor

      See identical proteins and their annotated locations for NP_001099334.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A0A8I6AH58, A6JSK2
      Related
      ENSRNOP00000091964.1, ENSRNOT00000095028.1
      Conserved Domains (1) summary
      PHA03247
      Location:678 → 832
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96680237..96691686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088079.2 → XP_038944007.1  scavenger receptor class F member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AH58
      Conserved Domains (2) summary
      PHA03247
      Location:619 → 773
      PHA03247; large tegument protein UL36; Provisional
      NF033759
      Location:114 → 367
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_039088078.2 → XP_038944006.1  scavenger receptor class F member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH58, D3ZBQ5
      Related
      ENSRNOP00000000313.6
      Conserved Domains (2) summary
      PHA03247
      Location:683 → 837
      PHA03247; large tegument protein UL36; Provisional
      NF033759
      Location:74 → 431
      exchanger_TraA; outer membrane exchange protein TraA
    Nucleotide Protein Strain
    Heading Accession and Version

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