Sipa1l2 signal-induced proliferation-associated 1 like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sipa1l2provided by RGD
Official Full Name: signal-induced proliferation-associated 1 like 2provided by RGD
Primary source: RGD:1306269
See related: Ensembl:ENSRNOG00000019791 AllianceGenome:RGD:1306269
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spar2; Sersap2
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Predicted to be active in cytoplasm. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 139.7), Lung (RPKM 120.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (70287134..70437810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (53389792..53540466, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (58236201..58399842, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vitro knockdown of SIPA1L2 in Schwannoma cells led to a significant reduction of PMP22 expression.
Title: Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A.
SPAR2 is a new RapGAP with specific functions in cerebellar and hippocampal granule cells.
Title: SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in presynaptic signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal-induced proliferation-associated 1-like protein 2

Names: SIPA1-like protein 2; serine-rich synapse associated protein 2; serine-rich synapse-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009704.2 → NP_001009704.2 signal-induced proliferation-associated 1-like protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q5JCS6

UniProtKB/TrEMBL

F1M8G8

Related

ENSRNOP00000026843.7, ENSRNOT00000026843.8

Conserved Domains (3) summary

cd00992
Location:951 → 1021

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:626 → 806

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1423 → 1666

SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

70287134..70437810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772639.3 → XP_008770861.1 signal-induced proliferation-associated 1-like protein 2 isoform X4

UniProtKB/Swiss-Prot

Q5JCS6

UniProtKB/TrEMBL

A0A8I5ZPJ4

Related

ENSRNOP00000080159.1

Conserved Domains (3) summary

cd00992
Location:951 → 1021

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:626 → 806

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1423 → 1604

SPAR_C; C-terminal domain of SPAR protein
XM_039097901.2 → XP_038953829.1 signal-induced proliferation-associated 1-like protein 2 isoform X3

UniProtKB/Swiss-Prot

Q5JCS6

Conserved Domains (3) summary

cd00992
Location:951 → 1021

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:626 → 806

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1423 → 1622

SPAR_C; C-terminal domain of SPAR protein
XM_008772638.3 → XP_008770860.1 signal-induced proliferation-associated 1-like protein 2 isoform X2

UniProtKB/Swiss-Prot

Q5JCS6

UniProtKB/TrEMBL

A0A8I6G2L5

Related

ENSRNOP00000078337.1

Conserved Domains (3) summary

cd00992
Location:951 → 1021

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:626 → 806

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1423 → 1648

SPAR_C; C-terminal domain of SPAR protein
XM_039097900.2 → XP_038953828.1 signal-induced proliferation-associated 1-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5JCS6

Conserved Domains (3) summary

cd00992
Location:951 → 1021

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:626 → 806

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1423 → 1685

SPAR_C; C-terminal domain of SPAR protein